Many novel therapies to treat myocardial infarction (MI), yielding promising results in animal
models, nowadays failed in clinical trials for several reasons. The most used animal MI …

Background Hypercholesterolemia is a major risk factor for ischemic heart disease including
acute myocardial infarction. However, long-term effects of hypercholesterolemia in a rodent …

Background Chronic inflammation plays a crucial role in the progression of cardiac fibrosis.
This study investigated whether inflammation exacerbated the progression of cardiac …

Objective To evaluate the protective effect of pravastatin on atherosclerotic development and
inflammatory monocyte subset in atherosclerotic apolipoprotein E (ApoE)−/− mice after …

Atherosclerotic plaques impair vascular function and can lead to arterial obstruction and
tissue ischaemia. Rupture of an atherosclerotic plaque within a coronary artery can result in …

Aims Myocardial ischaemia followed by reperfusion (IR) causes an oxidative burst resulting
in cellular dysfunction. Little is known about the impact of oxidative stress on cardiomyocyte …

Since little is known about the effects of reconstituted high-density lipoprotein (rHDL) in left
ventricular (LV) remodeling, these effects were examined in rats after acute myocardial …

Acute myocardial infarction is a common cardiovascular disease with high mortality.
Myocardial reperfusion injury can counteract the beneficial effects of heart reflow and induce …

Background—Hypercholesterolemia is prevalent in patients who experience myocardial
ischemia-reperfusion injury (IR). We investigate the impact of dietary-induced …

The past few years have witnessed a remarkable advance in our understanding of the
pathophysiology of coronary heart disease. Myocardial ischaemia usually occurs on the …