The mammalian sirtuins (SIRTs), comprising seven members (SIRT1–7) with different
cellular localization, play crucial roles in the maintenance of proper cellular functions …

Sirtuins represent a promising new class of conserved histone deacetylases, originally
identified in yeast. The activity of the sirtuin (SirT) family–made up of seven members (SirT1 …

Abstract Sirtuins (SIRT1–7), the mammalian homologues of the Sir2 gene in yeast, have
emerging roles in age-related diseases, such as cardiac hypertrophy, diabetes, obesity, and …

Sirtuins are a highly conserved family of nicotinamide adenine dinucleotide (NAD+)-
dependent protein lysine modifying enzymes with deacetylase, adenosine …

Abstract Sirtuin 2 (SIRT2) belongs to the sirtuins family. It exists in many tissues and organs
of the human body and regulates a wide range of biological functions. Studies have found …

Abstract Sirtuin 2 (SIRT2) is involved in a wide range of processes, from transcription to
metabolism to genome stability. Dysregulation of SIRT2 has been associated with the …

The sirtuin family has emerged as important regulators of diverse physiological and
pathological events, including life-span extension, neurodegeneration, age-related …

Among the greatest challenges facing organisms is that of detecting and effectively
responding to life-threatening environmental changes that are intimately associated with …

Sirtuins are involved in the control of the cell cycle and regulation of gene transcription.
While some sirtuins have tumor suppressor effects, others regulate tumors metabolism …

In the past decade, great interest has been shown in the role of sirtuin 1 (SIRT1) in
tumorigenesis. The published data show SIRT1 can function as both a tumor promoter and …