Tumour-stromal interactions have now been acknowledged to play a major role in
pancreatic cancer (PC) progression. The abundant collagenous stroma is produced by a …

Pancreatic stellate cells (PSCs) are responsible for producing the collagenous stroma in
pancreatic cancer. Findings from the majority of in vitro and in vivo studies to date indicate …

Pancreatic cancer is one of the most challenging adenocarcinomas due to its hostile
molecular behavior and complex tumor microenvironment. It has been recently postulated …

The stroma is a main driver of metastasis and aggressiveness in pancreatic cancer (PC),
one of the deadliest malignancies worldwide. Pancreatic stellate cells (PSCs) form …

Pancreatic ductal adenocarcinoma is a devastating disease, and patient outcomes have not
improved in decades. Treatments that target tumor cells have largely failed. This could be …

Pancreatic stellate cells (PSCs) were identified in the early 1980s, but received much
attention after 1998 when the methods to isolate and culture them from murine and human …

One of the characteristic features of the majority of pancreatic ductal adenocarcinomas is an
abundant desmoplastic/stromal reaction. Until recently, this stroma had received little …

Pancreatic cancer is associated with highly malignant tumors and poor prognosis due to
strong therapeutic resistance. Accumulating evidence shows that activated pancreatic …

Background The prognosis of pancreatic cancer remains desperately poor, with little
progress made over the past 30 years despite the development of new combination …

Pancreatic cancer is characterised by a prominent desmoplastic/stromal reaction. It is now
known that pancreatic stellate cells (PSCs) are the principal source of fibrosis in the stroma …