Interest in the role of B-cells in multiple sclerosis (MS) pathogenesis has increased, and a
number of B-cell targeted therapies are currently in clinical trials. B-cells are key mediators …

There is ongoing debate on how B cells contribute to the pathogenesis of multiple sclerosis
(MS). The success of B‐cell targeting therapies in MS highlighted the role of B cells …

Important antibody-independent pathogenic roles of B cells are emerging in autoimmune
diseases, including multiple sclerosis (MS). The contrasting results of different treatments …

Although many suspected autoimmune diseases are thought to be T cell-mediated, the
response to therapy indicates that depletion of B cells consistently inhibits disease activity. In …

Multiple sclerosis (MS) is a chronic disease of the central nervous system (CNS), in which
auto-aggressive lymphocytes participate in inflammation that causes myelin destruction …

Multiple sclerosis (MS) is a chronic autoimmune demyelinating disease of the central
nervous system (CNS) that often progresses to severe disability. Previous studies have …

B cells, plasma cells and antibodies may play a key role in the pathogenesis of multiple
sclerosis (MS). This notion is supported by various immunological changes observed in MS …

Multiple sclerosis (MS) is a chronic inflammatory neurological disease of the CNS that goes
along with demyelination and neurodegeneration. It is probably caused by an autoimmune …

While over the past decades T cells have been considered key players in the pathogenesis
of multiple sclerosis (MS), it has only recently become evident that B cells have a major …

Understanding the pathogenesis of complex immunologic disorders such as multiple
sclerosis (MS) is challenging. Abnormalities in many different cell types are observed in the …