B cells represent a relatively minor cell population within both the healthy and diseased
central nervous system (CNS), yet they can have profound effects. This is emphasized in …

There is growing recognition that B cell contributions to normal immune responses extend
well beyond their potential to become antibody-producing cells, including roles at the innate …

Highlights•B cells have regulatory functions in EAE and MS through IL-10 production.•The
differentiation of IL-10-producing B cells is associated to plasmocytes formation.• …

Multiple sclerosis (MS) is a severe disease of the central nervous system (CNS)
characterized by autoimmune inflammation and neurodegeneration. Historically, damage to …

The remarkable clinical efficacy of anti-CD20 monoclonal antibodies (mAb) in relapsing-
remitting multiple sclerosis points at the critical involvement of B cells in the disease …

2 are likely to be relevant to the pathogenesis of MS. Importantly, these T-cells reacted to
both latent and lytic EBV antigens, suggesting that latent-lytic EBV cycling boosts T-cell …

Therapy for relapsing–remitting multiple sclerosis (MS) has advanced dramatically despite
incomplete understanding of the cause of the condition. Current treatment involves inducing …

New treatments for multiple sclerosis (MS) focused on B cells have created an atmosphere
of excitement in the MS community. B cells are now known to play a major role in disease …

The role B cells and humoral immunity play in multiple sclerosis (MS) is continually evolving.
Recent discoveries include advances in lesion classification, identification of B cell clonal …

The onset of multiple sclerosis (MS) is caused by both genetic and environmental factors.
Among the environmental factors, it is believed that previous infection with Epstein–Barr …