Mounting evidence indicates that infection with Epstein–Barr virus (EBV) has a major role in
the pathogenesis of multiple sclerosis (MS). Defective elimination of EBV‐infected B cells by …

B cells are not limited to producing protective antibodies; they also perform additional
functions relevant to both health and disease. However, the relative contribution of …

B cells are involved in autoimmune diseases through both antibody-dependent and-
independent mechanisms. Broad depletion of B cells using monoclonal antibodies (mAbs) …

The pathogenic role for B cells in the context of relapsing remitting multiple sclerosis (MS) is
incompletely defined. Although classically considered a T cell-mediated disease, B cell …

Abstract The link between Epstein–Barr virus (EBV) and multiple sclerosis (MS) has puzzled
researchers since it was first discovered over 40 years ago. Until that point, EBV was …

Neuroinflammation can be defined as an inflammatory response within the central nervous
system (CNS) mediated by a complex crosstalk between CNS-resident and infiltrating …

The advent of therapies that specifically target the B‐lymphocyte lineage in human disease
has rejuvenated interest in the mechanistic biology by which B cells mediate autoimmunity …

B cells and T cells are two major players in the pathogenesis of multiple sclerosis (MS) and
cooperate at various check points. B cells, besides serving as a source for antibody …

Recent years have substantially broadened our view on the pathogenesis of multiple
sclerosis (MS). While earlier concepts focused predominantly on T lymphocytes as the key …

Multiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS) that
affects nearly two million people worldwide. Disease onset can occur at a young age …