B cells in systemic lupus erythematosus : Current Opinion in Rheumatology B cells in systemic
lupus erythematosus : Current Opinion in Rheumatology Log in or Register Subscribe to …

The role of B cells in autoimmune diseases involves different cellular functions, including the
well‐established secretion of autoantibodies, autoantigen presentation and ensuing …

New insights into the mechanisms of autoimmune diseases have been obtained not only
from preclinical studies, but also from clinical trials of pan-B-cell-directed therapy. Overall …

Multiple sclerosis is a chronic immune-mediated disease of the central nervous system that
has aspects of repetitive inflammatory activity as well as a slow neurodegenerative process …

Current clinical experience with immunomodulatory agents and monoclonal antibodies in
principle has established the benefit of depleting lymphocytic populations in relapsing …

Strong epidemiologic evidence links Epstein–Barr virus (EBV) infection and its altered
immune control to multiple sclerosis (MS) development. Clinical MS onset occurs years after …

B cells and their secreted products participate in the intricate network of pathogenic and
regulatory immune responses. In human autoimmune diseases like rheumatoid arthritis …

The remarkable success of anti‐CD20 B cell depletion therapies in reducing the burden of
multiple sclerosis (MS) disease has prompted significant interest in how B cells contribute to …

In spite of keen clinical and neuroscientific interest, the aetiology and immunopathology of
multiple sclerosis (MS) remain to be elucidated. The present work seeks to give insight into …

Reasons for targeting B cells in autoimmune disease date back to the discovery of
autoantibodies over 50yr ago [1]. The idea became of practical interest when anti-B cell …