Bone marrow regulatory T cells are a unique population, supported by niche-specific cytokines and plasmacytoid dendritic cells, and required for chronic graft-versus …

J Nicholls, B Cao, L Le Texier, LY Xiong… - Frontiers in Cell and …, 2021 - frontiersin.org
Regulatory T cell (Treg) reconstitution is essential for reestablishing tolerance and
maintaining homeostasis following stem-cell transplantation. We previously reported that …

Harnessing bone marrow resident regulatory T cells to improve allogeneic stem cell transplant outcomes

L Le Texier, KE Lineburg, KPA MacDonald - International journal of …, 2017 - Springer
Regulatory T cells (Treg) are a suppressive T cell population which play a crucial role in the
establishment of tolerance after stem cell transplantation (SCT) by controlling the effector T …

[HTML][HTML] Autophagy-dependent regulatory T cells are critical for the control of graft-versus-host disease

L Le Texier, KE Lineburg, B Cao, C McDonald-Hyman… - JCI insight, 2016 - ncbi.nlm.nih.gov
Regulatory T cells (Tregs) play a crucial role in the maintenance of peripheral tolerance.
Quantitative and/or qualitative defects in Tregs result in diseases such as autoimmunity …

Autologous stem cell transplantation aids autoimmune patients by functional renewal and TCR diversification of regulatory T cells

EM Delemarre, T Van Den Broek… - Blood, The Journal …, 2016 - ashpublications.org
Autologous hematopoietic stem cell transplantation (HSCT) is increasingly considered for
patients with severe autoimmune diseases whose prognosis is poor with standard …

Selective Treg reconstitution during lymphopenia normalizes DC costimulation and prevents graft-versus-host disease

HA Bolton, E Zhu, AM Terry, TV Guy… - The Journal of …, 2015 - Am Soc Clin Investig
Regulatory T cells (Tregs) have been shown to enhance immune reconstitution and prevent
graft-versus-host disease (GVHD) after hematopoietic stem cell transplantation; however, it …

Recipient Tregs: can they be exploited for successful hematopoietic stem cell transplant outcomes?

SN Copsel, D Wolf, B Pfeiffer, H Barreras… - Frontiers in …, 2022 - frontiersin.org
Human and mouse CD4+ FoxP3+ T cells (Tregs) comprise non-redundant regulatory
compartments which maintain self-tolerance and have been found to be of potential …

[HTML][HTML] Marked in vivo donor regulatory T cell expansion via interleukin-2 and TL1A-Ig stimulation ameliorates graft-versus-host disease but preserves graft-versus …

D Wolf, H Barreras, CS Bader, S Copsel… - Biology of blood and …, 2017 - Elsevier
Regulatory T cells (Tregs) are critical for self-tolerance. Although adoptive transfer of
expanded Tregs limits graft-versus-host disease (GVHD) after hematopoietic stem cell …

[HTML][HTML] Regulatory T cell niche in the bone marrow, a new player in Haematopoietic stem cell transplantation

J Ashman, N Mutsonziwa, M Romano, S Kordasti… - Blood Reviews, 2023 - Elsevier
Challenges in haematopoietic stem cell transplantation such as low bone marrow (BM)
engraftment, graft versus host disease (GvHD) and the need for long-term …

Foxp3+ regulatory T cells maintain the bone marrow microenvironment for B cell lymphopoiesis

A Pierini, H Nishikii, J Baker, T Kimura, HS Kwon… - Nature …, 2017 - nature.com
Foxp3+ regulatory T cells (Treg cells) modulate the immune system and maintain self-
tolerance, but whether they affect haematopoiesis or haematopoietic stem cell (HSC) …

Regulatory T-cell immunotherapy for allogeneic hematopoietic stem-cell transplantation

M Horch, VH Nguyen - Therapeutic Advances in Hematology, 2012 - journals.sagepub.com
From mouse studies to recently published clinical trials, evidence has accumulated on the
potential use of regulatory T cells (Treg) in preventing and treating graft-versus-host disease …