The interferon-induced host restriction factor tetherin poses a barrier for SIV transmission
from primates to humans. After cross-species transmission, the chimpanzee precursor of …

The host restriction factor tetherin inhibits virion release from infected cells and poses a
significant barrier to successful zoonotic transmission of primate lentiviruses to humans …

Most simian immunodeficiency viruses use their Nef protein to antagonize the host
restriction factor tetherin. A deletion in human tetherin confers Nef resistance, representing a …

Simian immunodeficiency viruses (SIVs) use their Nef proteins to counteract the restriction
factor tetherin. However, a deletion in human tetherin prevents antagonism by the Nef …

Primate lentiviruses including human immunodeficiency virus type 1 (HIV-1) and simian
immunodeficiency viruses (SIVs) evolved through the acquisition of antagonists against …

Bone Marrow Stromal Cell Antigen 2 (BST-2)/tetherin inhibits the release of numerous
enveloped viruses by physically tethering nascent particles to infected cells during the …

Although Nef is the viral gene product used by most simian immunodeficiency viruses to
overcome restriction by tetherin, this activity was acquired by the Vpu protein of HIV-1 group …

Nef is the viral gene product employed by the majority of primate lentiviruses to overcome
restriction by tetherin (BST-2 or CD317), an interferon-inducible transmembrane protein that …

Summary The tetherin/BST2/CD317 protein blocks the release of HIV-1 and other
enveloped viruses by inducing tethering of nascent particles to infected cell surfaces. The …

Tetherin is a host defense factor that physically prevents virion release from the plasma
membrane. The Nef accessory protein of simian immunodeficiency virus (SIV) engages the …