The use of corticosteroids in the treatment of steroid-sensitive nephrotic (SSNS) syndrome in
children has evolved surprisingly slowly since the ISKDC consensus over 50 years ago …

Idiopathic nephrotic syndrome, although a rare disease, is the most common primary
glomerular disease among children. It causes substantial morbidity because it typically runs …

Background Reduction of steroid exposure in relapses of steroid-sensitive nephrotic
syndrome (SSNS) is under-researched. Methods In this randomized controlled non …

The International Study of Kidney Disease in Children (ISKDC) arbitrarily determined a
standard-dose prednisolone regimen for the first episode of nephrotic syndrome [1]. This …

The best initial therapy for steroid-sensitive nephrotic syndrome (SSNS) in children is
subject to ongoing debate. Systematic reviews and meta-analyses have concluded that at …

BACKGROUND The optimal corticosteroid regimen for treating the presenting episode of
steroid-sensitive nephrotic syndrome (SSNS) remains uncertain. Most UK centres use an 8 …

Corticosteroid-related toxicity in children with steroid-sensitive nephrotic syndrome is
primarily related to the cumulative dose of prednisone. To optimize treatment of relapses, we …

Using data from systematic reviews and randomised controlled trials, the evidence for
managing steroid sensitive nephrotic syndrome (SSNS) is reviewed. In the initial episode …

While studies show that prolonged initial prednisone therapy reduces the frequency of
relapses in nephrotic syndrome, they lack power and have risk of bias. In order to examine …

Nephrotic syndrome is one of the most common paediatric glomerular diseases, with an
incidence of around two per 100 000 children per year. Corticosteroids are the mainstay of …