Troxerutin attenuates enhancement of hepatic gluconeogenesis by inhibiting NOD activation-mediated inflammation in high-fat diet-treated mice
Z Zhang, X Wang, G Zheng, Q Shan, J Lu… - International journal of …, 2016 - mdpi.com
Recent evidence suggests that troxerutin, a trihydroxyethylated derivative of natural
bioflavonoid rutin, exhibits beneficial effects on diabetes-related symptoms. Here we …
bioflavonoid rutin, exhibits beneficial effects on diabetes-related symptoms. Here we …
Cyanidin 3-glucoside attenuates obesity-associated insulin resistance and hepatic steatosis in high-fat diet-fed and db/db mice via the transcription factor FoxO1
H Guo, M Xia, T Zou, W Ling, R Zhong… - The Journal of nutritional …, 2012 - Elsevier
Obesity is a major risk factor for the development of type 2 diabetes, and both conditions are
now recognized to possess significant inflammatory components underlying their …
now recognized to possess significant inflammatory components underlying their …
Troxerutin protects against high cholesterol-induced cognitive deficits in mice
J Lu, D Wu, Z Zheng, Y Zheng, B Hu, Z Zhang - Brain, 2011 - academic.oup.com
Recent findings suggest that neurotoxicity is the mechanism underlying the induction of
neuronal insulin resistance by a high cholesterol diet. Troxerutin, a naturally occurring …
neuronal insulin resistance by a high cholesterol diet. Troxerutin, a naturally occurring …
The antioxidant silybin prevents high glucose-induced oxidative stress and podocyte injury in vitro and in vivo
K Khazim, Y Gorin, RC Cavaglieri… - American journal of …, 2013 - journals.physiology.org
Podocyte injury, a major contributor to the pathogenesis of diabetic nephropathy, is caused
at least in part by the excessive generation of reactive oxygen species (ROS) …
at least in part by the excessive generation of reactive oxygen species (ROS) …
Resveratrol improves oxidative stress and protects against diabetic nephropathy through normalization of Mn-SOD dysfunction in AMPK/SIRT1-independent pathway
M Kitada, S Kume, N Imaizumi, D Koya - Diabetes, 2011 - Am Diabetes Assoc
OBJECTIVE Despite the beneficial effects of resveratrol (RSV) on cardiovascular disease
and life span, its effects on type 2 diabetic nephropathy remain unknown. This study …
and life span, its effects on type 2 diabetic nephropathy remain unknown. This study …
Antidiabetic effects of nerolidol through promoting insulin receptor signaling in high-fat diet and low dose streptozotocin-induced type 2 diabetic rats
N Jiang, Y Zhang - Human & experimental toxicology, 2022 - journals.sagepub.com
The present study was designed to investigate the antidiabetic effect of nerolidol on high-fat
diet and streptozotocin-induced diabetic rats. Type 2 diabetes was induced in animals by …
diet and streptozotocin-induced diabetic rats. Type 2 diabetes was induced in animals by …
Osthole ameliorates early diabetic kidney damage by suppressing oxidative stress, inflammation and inhibiting TGF-β1/Smads signaling pathway
Q Li, Y Wang, J Yan, R Yuan, J Zhang, X Guo… - International …, 2024 - Elsevier
Background Osthole is a natural active ingredient extracted from the traditional Chinese
medicine Cnidium monnieri. It has been demonstrated to have anti-inflammatory, anti …
medicine Cnidium monnieri. It has been demonstrated to have anti-inflammatory, anti …
Diosgenin modulates oxidative stress and inflammation in high-fat diet-induced obesity in mice
Introduction Obesity is a chronic metabolic disorder that results in excessive energy
accumulated in adipose tissue causing dysfunction of adipocytes, inflammation, and …
accumulated in adipose tissue causing dysfunction of adipocytes, inflammation, and …
Crucial roles of N ox2‐derived oxidative stress in deteriorating the function of insulin receptors and endothelium in dietary obesity of middle‐aged mice
J Du, LM Fan, A Mai, JM Li - British journal of pharmacology, 2013 - Wiley Online Library
Background and Purpose Systemic oxidative stress associated with dietary calorie overload
plays an important role in the deterioration of vascular function in middle‐aged patients …
plays an important role in the deterioration of vascular function in middle‐aged patients …
Resveratrol prevents renal lipotoxicity and inhibits mesangial cell glucotoxicity in a manner dependent on the AMPK–SIRT1–PGC1α axis in db/db mice
MY Kim, JH Lim, HH Youn, YA Hong, KS Yang… - Diabetologia, 2013 - Springer
Aims/hypothesis Many of the effects of resveratrol are consistent with the activation of AMP-
activated protein kinase (AMPK), silent information regulator T1 (SIRT1) and peroxisome …
activated protein kinase (AMPK), silent information regulator T1 (SIRT1) and peroxisome …