Background/Aims: Previous studies have suggested that myricetin (Myr) could promote the
expression and nuclear translocation of nuclear factor (erythroid-derived 2)-like (Nrf2). This …

Atrasentan is a promising therapy for treating diabetic nephropathy (DN). Here we evaluated
whether atrasentan down-regulated the miR-199b-5p expression, thereby increasing klotho …

Hyperglycemia-mediated oxidative stress plays a crucial role in the progression of diabetic
nephropathy. Hence, the present study was hypothesized to explore the renoprotective …

Diabetes causes diabetic nephropathy (DN) which is associated with increased morbidity
and mortality in diabetic patients. We tested whether Resveratrol (Res) reverses the …

Diabetes mellitus, a major global health concern, is emerging as the primary human disease
in the twenty-first century, with beta cell damage and dysfunction playing a critical role …

Since lycopene has antioxidant activity, its combination with metformin may be useful to
contrast diabetic complications related to oxidative stress. This study aimed to investigate …

High fat diet, as an important risk factor, plays a pivotal role in atherosclerotic process.
Celastrol is one of the active triterpenoid compounds with antioxidative and anti …

Sarcopenia refers to a decline in muscle mass and strength with age, causing significant
impairment in the ability to carry out normal daily functions and increased risk of falls and …

Oxidative stress in adipose tissue is a crucial pathogenic mechanism of obesity-associated
cardiovascular diseases. Chronic low-grade inflammation caused by obesity increases ROS …

Obesity-associated nephropathy is considered to be a leading cause of end-stage renal
disease. Resveratrol supplementation represents a promising therapy to attenuate kidney …