Myoglobin (Mb) is a regulator of O2 bioavailability in type I muscle and heart, at least when
tissue O2 levels drop. Mb also plays a role in regulating cellular nitric oxide (NO) pools …

Recent studies of myoglobin (Mb) knockout (myo−/−) mice have extended our
understanding of Mb's diverse functions and have demonstrated a complex array of …

Myoglobin (Mb) plays an important role at rest and during exercise as a reservoir of oxygen
and has been suggested to regulate NO• bioavailability under hypoxic/acidic conditions …

Myoglobin (Mb) is an oxygen-binding muscular hemeprotein regulated via Ca2+-signaling
pathways involving calcineurin (CN), with Mb increases attributed to hypoxia, exercise, and …

A canonical view of the primary physiological function of myoglobin (Mb) is that it is an
oxygen (O2) storage protein supporting mitochondrial oxidative phosphorylation, especially …

Myoglobin (Mb) regulates O2 bioavailability in muscle and heart as the partial pressure of
O2 (Po2) drops with increased tissue workload. Globin proteins also modulate cellular NO …

The identification of novel physiological regulators that stimulate energy expenditure
through brown adipose tissue (BAT) activity in substrate catalysis is of utmost importance to …

Myoglobin is an important intracellular O2 binding hemoprotein in heart and skeletal muscle.
Surprisingly, disruption of myoglobin in mice (myo−/−) resulted in no obvious phenotype and …

Myoglobin may serve a variety of functions in muscular oxygen supply, such as O2 storage,
facilitated O2 diffusion, and myoglobin-mediated oxidative phosphorylation. We studied the …

Recent studies have suggested myoglobin (Mb) may have other cellular functions in
addition to storing and transporting O 2. Indeed, NMR experiments have shown that the …