It is well recognized that diet-induced dysfunctions in skeletal muscle are closely related with
many metabolic diseases, such as obesity and diabetes. In the present study, we identified …

THE EFFECTS OF HYPOXIA on mammalian heart and muscle have fascinated physiologists
for many a day. Myoglobin is expressed adaptively in muscle. In very young animals, and in …

Metabolic demands of skeletal muscle are substantial and are characterized normally as
highly flexible and with a large dynamic range. Skeletal muscle composition (eg, fiber type …

Key points Although they are unable to utilize muscle glycogen, McArdle mice adapt
favourably to an individualized moderate‐intensity endurance exercise training regime. Yet …

Since their initial discovery over a century ago, our knowledge of the functions of myoglobin
and the mitochondrion has gradually evolved. The mitochondrion, once thought to be solely …

It has become increasingly apparent that substrate metabolism is subject to gender-specific
regulation, and the aim of this review is to outline the available evidence of molecular …

Skeletal muscle plays an integral role in coordinating physiological homeostasis, where
signaling to other tissues via myokines allows for coordination of complex processes. Here …

Myoglobin is an oxygen storage molecule that is selectively expressed in cardiac and slow-
twitch skeletal muscles that have a high oxygen demand. Numerous studies have implicated …

Low birth weight (LBW) offspring are at increased risk for developing insulin resistance, a
key precursor in metabolic syndrome and type 2 diabetes mellitus. Altered skeletal muscle …

Women typically have less muscle mass and more fat mass than men, while at the same
time possessing similar or even greater whole‐body insulin sensitivity. Our study aimed to …