TRPV1 (transient receptor potential vanilloid 1) is a ligand-gated ion channel expressed
predominantly in nociceptive primary afferents that plays a key role in pain processing. In …

Purpose. TRPV1 is a multimodal channel mainly expressed in sensory neurons. We aimed
to explore the pharmacodynamics of the TRPV1 agonists, capsaicin, natural capsaicinoids …

TRPV1 (vanilloid receptor 1) receptors are activated by a variety of ligands such as
capsaicin, as well as by acidic conditions and temperatures above 42° C. These activators …

Capsiate is a capsaicin-like ingredient of a non-pungent cultivar of red pepper, CH-19
sweet. To elucidate the mechanisms underlying the non-pungency of capsiate, we …

Background Transient receptor potential vanilloid type 1 (TRPV1) is a non-selective cation
channel widely expressed in skin tissues, and peripheral sensory nerve fibres. Activation of …

Capsaicin and other naturally occurring pungent molecules have been used for centuries as
topical analgesics to treat a variety of painful conditions. However, only within the last 12 …

The capsaicin receptor, TRPV1,(transient receptor potential channel-vanilloid subfamily
member 1) is a cation channel subunit expressed by a subset of nociceptive neurons in …

The vanilloid receptor TRPV1 is a ligand-gated cation channel that can be activated by
capsaicin, acids and noxious heat. For vanilloids, a stretch of 8 amino acids in the vicinity of …

The transient receptor potential vanilloid‐1 (TRPV1) cation channel is a receptor that is
activated by heat (> 42° C), acidosis (pH< 6) and a variety of chemicals among which …

N-acyl-vanillamide (NAVAM) analogues of the natural pungent principle of capsicum,
capsaicin, were developed several years ago as potential non-pungent analgesic …