[HTML][HTML] Immunomic Investigation of Holocyclotoxins to Produce the First Protective Anti-Venom Vaccine Against the Australian Paralysis Tick, Ixodes holocyclus

M Rodriguez-Valle, S McAlister… - Frontiers in …, 2021 - frontiersin.org
Venom producing animals are ubiquitously disseminated among vertebrates and
invertebrates such as fish, snakes, scorpions, spiders, and ticks. Of the~ 890 tick species …

Transcriptome and toxin family analysis of the paralysis tick, Ixodes holocyclus

M Rodriguez-Valle, P Moolhuijzen, RA Barrero… - International journal for …, 2018 - Elsevier
Abstract The Australian paralysis tick (Ixodes holocyclus) secretes neuropathic toxins into
saliva that induce host paralysis. Salivary glands and viscera were dissected from fully …

[HTML][HTML] Exploring the transcriptomic data of the Australian paralysis tick, Ixodes holocyclus

CT Ong, M Rodriguez-Valle, PM Moolhuijzen… - GSTF Journal of …, 2016 - Springer
Ixodes holocyclus is the paralysis tick commonly found in Australia. I. holocyclus does not
cause paralysis in the primary host–bandicoots, but markedly affects secondary hosts such …

[HTML][HTML] Tick holocyclotoxins trigger host paralysis by presynaptic inhibition

KK Chand, KM Lee, NA Lavidis, M Rodriguez-Valle… - Scientific Reports, 2016 - nature.com
Ticks are important vectors of pathogens and secreted neurotoxins with approximately 69
out of 692 tick species having the ability to induce severe toxicoses in their hosts. The …

[HTML][HTML] A review of Australian tick vaccine research

AE Tabor - Vaccines, 2021 - mdpi.com
Tick vaccine research in Australia has demonstrated leadership worldwide through the
development of the first anti-tick vaccine in the 1990s. Australia's Commonwealth Scientific …

Holocyclotoxin-1, a cystine knot toxin from Ixodes holocyclus

S Vink, NL Daly, N Steen, DJ Craik, PF Alewood - Toxicon, 2014 - Elsevier
In the past 100 years minimal venom research has focused on ticks despite several species
possessing a highly paralytic and lethal venom cocktail of proteinaceous molecules. The …

Tick paralysis: development of a vaccine

S Masina, KW Broady - International Journal for Parasitology, 1999 - Elsevier
The paralysis tick of Australia, Ixodes holocyclus, causes a severe toxicosis in domestic
animals such as dogs and cats, livestock, and in some cases, humans. It is characterised by …

Tick/host interactions forIxodes holocyclus: Role, effects, biosynthesis and nature of its toxic and allergenic oral secretions

BF Stone, KC Binnington, M Gauci… - Experimental & Applied …, 1989 - Springer
Abstract The Australian paralysis tick Ixodes holocyclus occurs along the eastern coast of
Australia. Its interaction with a wide variety of hosts causes a serious toxicosis (tick paralysis) …

The use of tick antitoxin serum and associated therapy for the treatment of dogs with Ixodes holocyclus toxicity.

DN Schull, CA O'Leary - 2007 - cabidigitallibrary.org
The administration of tick antitoxin serum is an important component of the treatment of
Ixodes holocyclus toxicity in Australian dogs. Available recommendations for the use of tick …

Tick paralysis in Australia caused by Ixodes holocyclus Neumann

S Hall‐Mendelin, SB Craig, RA Hall… - Annals of Tropical …, 2011 - Taylor & Francis
Ticks are obligate haematophagous ectoparasites of various animals, including humans,
and are abundant in temperate and tropical zones around the world. They are the most …