The discovery of leptin changed the view of adipose tissue from that of a passive vessel that
stores fat to that of a dynamic endocrine organ that actively regulates behaviour and …

Leptin is an adipose tissue hormone that functions as an afferent signal in a negative
feedback loop that maintains homeostatic control of adipose tissue mass. This endocrine …

Historically, adipose tissue was considered to be a passive storage vessel discharging
nutrients in times of famine and accumulating fat in times of surfeit. This view changed with …

Abstract The 2010 Lasker Award for basic medical research was shared by Douglas
Coleman and Jeffery Friedman for their discovery of leptin, a breakthrough that revealed …

The adipocyte-derived hormone, leptin, regulates food intake and systemic fuel metabolism;
ob/ob mice, which lack functional leptin, exhibit an obesity syndrome that is similar to morbid …

Leptin, discovered through positional cloning 15 years ago, is an adipocyte-secreted
hormone with pleiotropic effects in the physiology and pathophysiology of energy …

The discovery of the obese gene and the demonstration that its encoded protein leptin can
reverse obesity due to genetic deficiency of the hormone were landmark discoveries in …

▪ Abstract The discovery of the adipose-derived hormone leptin has generated enormous
interest in the interaction between peripheral signals and brain targets involved in the …

Leptin has received considerable attention as a newly recognized metabolic hormone and
for its potential for therapeutic use in the treatment of human obesity. Furthermore, defects in …

The discovery of leptin has provided a robust framework upon which our current
understanding of the mechanisms involved in energy homeostasis has been built. In this …