Effect of clinical mutations on functionality of the human riboflavin transporter-2 (hRFT-2)

SM Nabokina, VS Subramanian, HM Said - Molecular genetics and …, 2012 - Elsevier
The Brown–Vialetto–Van Laere syndrome (BVVLS) is a rare neurological disease
characterized by ponto-bulbar palsy, bilateral sensorineural deafness, and respiratory …

Riboflavin transporters RFVT/SLC52A mediate translocation of riboflavin, rather than FMN or FAD, across plasma membrane

C Jin, Y Yao, A Yonezawa, S Imai… - Biological and …, 2017 - jstage.jst.go.jp
Riboflavin (vitamin B2) plays a role in various biochemical oxidation-reduction reactions.
Flavin mononucleotide (FMN) and FAD, the biologically active forms, are made from …

Chronic alcohol feeding inhibits physiological and molecular parameters of intestinal and renal riboflavin transport

VS Subramanian, SB Subramanya… - … of Physiology-Cell …, 2013 - journals.physiology.org
Vitamin B2 (riboflavin, RF) is essential for normal human health. Mammals obtain RF from
exogenous sources via intestinal absorption and prevent its urinary loss by reabsorption in …

Riboflavin transporter is finally identified

Y Moriyama - The journal of biochemistry, 2011 - academic.oup.com
Riboflavin or vitamin B2 is one of the constituents of energy drinks. Although this compound
is known to be absorbed in the intestine and that it circulates throughout the body and is …

Identification and Functional Characterization of the Caenorhabditis elegans Riboflavin Transporters rft-1 and rft-2

A Biswas, D Elmatari, J Rothman, CW LaMunyon… - PLoS …, 2013 - journals.plos.org
Two potential orthologs of the human riboflavin transporter 3 (hRFVT3) were identified in the
C. elegans genome, Y47D7A. 16 and Y47D7A. 14, which share 33.7 and 30.5% identity …

Impact of natural mutations on the riboflavin transporter 2 and their relevance to human riboflavin transporter deficiency 2

L Console, M Tolomeo, J Cosco, K Massey… - IUBMB …, 2022 - Wiley Online Library
Abstract Riboflavin transporter deficiency 2 (RTD2) is a rare neurological disorder caused by
mutations in the Solute carrier family 52 member 2 (Slc52a2) gene encoding human …

Evaluation of riboflavin transporters as targets for drug delivery and theranostics

L Bartmann, D Schumacher, S Von Stillfried… - Frontiers in …, 2019 - frontiersin.org
The retention and cellular internalization of drug delivery systems and theranostics for
cancer therapy can be improved by targeting molecules. Since an increased uptake of …

Riboflavin uptake transporter Slc52a2 (RFVT2) is upregulated in the mouse mammary gland during lactation

AML Wu, L Dedina, P Dalvi, M Yang… - American Journal …, 2016 - journals.physiology.org
While it is well recognized that riboflavin accumulates in breast milk as an essential vitamin
for neonates, transport mechanisms for its milk excretion are not well characterized. The …

Differentiation-dependent regulation of intestinal vitamin B2 uptake: studies utilizing human-derived intestinal epithelial Caco-2 cells and native rat intestine

VS Subramanian, A Ghosal… - American Journal …, 2013 - journals.physiology.org
Intestinal epithelial cells undergo differentiation as they move from the crypt to the villi, a
process that is associated with up-and downregulation in expression of a variety of genes …

Regulation of intestinal vitamin B2 absorption Focus on “Riboflavin uptake by human-derived colonic epithelial NCM460 cells”

U Sundaram - American Journal of Physiology-Cell …, 2000 - journals.physiology.org
RIBOFLAVIN OR VITAMIN B2 (7, 8-dimethyl-10-ribitylisoalloxazine) is an essential water-
soluble vitamin. Riboflavin is important for normal cell functioning and for cell growth and …