Urinary bladder pain is a primary symptom associated with interstitial cystitis/painful bladder
syndrome. We used systemic injections of cyclophosphamide (CYP), an alkylating …

Transient receptor potential vanilloid 1 (TRPV1) is highly expressed in primary afferent
neurons. Tissue damage generates an array of chemical mediators that activate and …

Using patch-clamp techniques, we studied the plasticity of acid-sensing ion channels (ASIC)
and transient receptor potential V1 (TRPV1) channel function in dorsal root ganglia (DRG) …

PURPOSE: We evaluated the effects of GRC-6211, an orally active TRPV1 antagonist, on
the function and noxious input of naïve and inflamed bladders. MATERIALS AND …

Abstract Both TRPV1 and P2X receptors present on bladder sensory nerve fibres have been
implicated in mechanosensation during bladder filling. The aim of this study was to …

Background and Purpose Interstitial cystitis (= painful bladder syndrome) is a chronic
bladder syndrome characterised by pelvic and bladder pain, urinary frequency and urgency …

Interstitial cystitis/bladder pain syndrome (IC/BPS) is a type of chronic bladder inflammation
characterized by increased voiding frequency, urgency and pelvic pain. The sensitization of …

PURPOSE: We investigated the pharmacological effect of TRPV1 antagonists in
anesthetized rodent models of bladder function. MATERIALS AND METHODS: The TRPV1 …

Purpose During cystitis, increased innervation of the bladder by sensory nerves may
contribute to bladder overactivity and pain. The mechanisms whereby cystitis leads to …

Background Interstitial cystitis/painful bladder syndrome (IC/PBS) is a bladder disease that
causes debilitating pelvic pain of unknown origin, and IC/PBS symptoms correlate with …