The year 2023 marks the 25 th anniversary of the discovery of RNA interference (RNAi).
RNAi-based therapeutics enable sequence-specific gene knockdown by eliminating target …

A resurgence in clinical trials using RNA interference (RNAi) occurred in 2012. Although
there were initial difficulties in achieving efficacious results with RNAi without toxic side …

With unprecedented speed, RNA interference (RNAi) has advanced from its basic discovery
in lower organisms to becoming a powerful genetic tool and perhaps our single most …

RNA interference (RNAi) is a collection of small RNA directed mechanisms that result in
sequence specific inhibition of gene expression. The notion that RNAi could lead to a new …

RNA interference (RNAi) is a natural cellular process that regulates gene expression by a
highly precise mechanism of sequence-directed gene silencing at the stage of translation by …

RNA interference (RNAi) was discovered less than a decade ago and already there are
human clinical trials in progress or planned. A major advantage of RNAi versus other …

Since the demonstration of RNA interference (RNAi) in mammalian cells, considerable
research and financial effort has gone towards implementing RNAi as a viable therapeutic …

RNA interference (RNAi) has rapidly advanced from a laboratory observation into a major
area of research within biology and medicine. RNAi is triggered by short interfering RNAs …

RNAi Therapeutics: How Likely, How Soon? | PLOS Biology Skip to main content
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Inherent difficulties with blocking many desirable targets using conventional approaches
have prompted many to consider using RNA interference (RNAi) as a therapeutic approach …