Structure-antitumour activity relationships for new platinum complexes

DG Craciunescu, A Doadrio, A Furlani… - Chemico-Biological …, 1982 - Elsevier
Fourteen platinum (Pt) coordination complexes with different ligands, which include both Pt
(II) and Pt (IV) complexes, were prepared, characterized and tested for their in vitro cytotoxic …

Activity of some platinum (II/IV) complexes with O, On-butyl-and O, On-pentyl-ethylenediamine-N, N′-di-3-propanoate and halogeno ligands against HeLa and K562 …

GN Kaluđerović, VM Đinović, ZD Juranić… - Journal of inorganic …, 2005 - Elsevier
This paper reports on syntheses and characterization of chlorotribromo (O, On-butyl-
ethylenediamine-N, N′-di-3-propanoate) platinum (IV)[II], dichlorodiiodo (O, On-butyl …

Antiproliferative activity of some cis-/trans-platinum (II) complexes on HeLa cells.

S Arandjelovic, Z Tesic, Z Juranic… - … of Experimental & …, 2002 - europepmc.org
Purpose of this work was to synthesize several cis-/trans-isomer pairs of the platinum (II)
complexes, and study the extent and the mode of their antiproliferative activity on HeLa cells …

ON THE PREPARATION, ANTITUMOUR AND CYTO-TOXIC EVALUATION OF SOME NEW ANALOGS OF THE CIS-DICHLORO (1, 2-DIAMINO-CYCLOHEXANE) …

DG Craciunescu, A Doadrio, AC Furlani… - European journal of …, 1984 - hero.epa.gov
ON THE PREPARATION, ANTITUMOUR AND CYTO-TOXIC EVALUATION OF SOME NEW
ANALOGS OF THE CIS-DICHLORO (1,2-DIAMINO-CYCLOHEXANE) PLATINUM(II) COMPLEX …

Structure-activity relations of antineoplastic platinum II and platinum IV coordination compounds

W Gutsche, J Baumgart, HP Schröer - Archiv fur …, 1989 - europepmc.org
Five diammine-Pt (II) or Pt (IV) coordination compounds, namely cis-diammine-dichloro-
platinum (II)" cis-DDP", transdihydroxy-cis-diammine-dichloro-platinum (IV)" trans-ODDP" …

Factor analysis of in vitro antitumor activities of platinum complexes

H KURAMOCHI, A MOTEGI, S MARUYAMA… - Chemical and …, 1990 - jstage.jst.go.jp
抄録 Factor analysis was applied to the data matrix of in vitro growth inhibitory activities of 52
platinum complexes against 9 tumor cell lines, L1210, P388, Lewis lung, AH66, AH66F …

Crystal structure, solution chemistry, and antitumor activity of diastereomeric [1, 2-bis (2-hydroxyphenyl) ethylenediamine] dichloroplatinum (II) complexes

R Gust, H Schoenenberger, J Kritzenberger… - Inorganic …, 1993 - ACS Publications
Ks is the rate constant for the h coordination after hydrolysis and k\-the rate constant for the
direct nucleophilic attack. Due to the shielding of the platinum by the axially oriented …

Synthesis and antitumor activity of cis-platinum complexes of aromatic amines

T OSA, H HINO, S FUJIEDA, F SHIMIZU… - Chemical and …, 1986 - jstage.jst.go.jp
Six synthesized cis-dichloro platinum (II) complexes which coordinate bis (4-aminophenol),
bis (3-toluidine), bis (2-aminobiphenyl), bis (4-sulfamidoaniline), bis (l—naphthylamine) and …

In Vitro Cytotoxic‐Active Platinum (II) Complexes Derived from Carboplatin and Involving Purine Derivatives

L Dvořák, I Popa, P Štarha, Z Trávníček - 2010 - Wiley Online Library
Six platinum (II) complexes of the general formula [Pt (cbdc)(HLn) 2](1–6; cbdc= cyclobutane‐
1, 1‐dicarboxylate and HL1–HL6= benzyl‐substituted 6‐benzylamino‐2‐chloro‐9 …

[HTML][HTML] Synthesis, characterization, crystal structures and cytotoxic activity of Pt (II) complexes with N, N-donor ligands in tumor cell lines

E Fernández-Delgado, S Estirado, AB Rodríguez… - Polyhedron, 2024 - Elsevier
Cisplatin is one of the most used chemotherapeutic agents nowadays. However, it presents
several and severe side effects. For that, the synthesis of new analogues of cisplatin is …