GABAB receptor ligand-directed trimethyl chitosan/tripolyphosphate nanoparticles and their pMDI formulation for survivin siRNA pulmonary delivery
S Ni, Y Liu, Y Tang, J Chen, S Li, J Pu, L Han - Carbohydrate polymers, 2018 - Elsevier
The effect of gene silencing by survivin siRNA (siSurvivin) on the proliferation and apoptosis
of lung tumor has been attracted more interest. GABA B receptor ligand-directed …
of lung tumor has been attracted more interest. GABA B receptor ligand-directed …
Anti-tumor effects in mice induced by survivin-targeted siRNA delivered through polysaccharide nanoparticles
Recently, survivin has been attracting great attention because it plays an important role in
inhibiting the apoptosis process of tumor cells. Down-regulating the expression of survivin …
inhibiting the apoptosis process of tumor cells. Down-regulating the expression of survivin …
Nebulized anionic guanidinylated O-carboxymethyl chitosan/N-2-hydroxypropyltimehyl ammonium chloride chitosan nanoparticles for siRNA pulmonary delivery …
S Ni, Y Xie, Y Tang, Y Liu, J Chen… - Journal of Drug Targeting, 2017 - Taylor & Francis
This study developed a pH-sensitive anionic system composed of guanidinylated O-
carboxymethyl chitosan (GOCMCS) and N-2-hydroxypropyltimehyl ammonium chloride …
carboxymethyl chitosan (GOCMCS) and N-2-hydroxypropyltimehyl ammonium chloride …
[HTML][HTML] Apoptosis of A549 cells by small interfering RNA targeting survivin delivery using poly-β-amino ester/guanidinylated O-carboxymethyl chitosan nanoparticles
Y Tang, Y Liu, Y Xie, J Chen, Y Dou - Asian Journal of Pharmaceutical …, 2020 - Elsevier
Gene-based therapeutics has emerged as a promising approach for human cancer therapy.
Among a variety of non-viral vectors, polymer vectors are particularly attractive due to their …
Among a variety of non-viral vectors, polymer vectors are particularly attractive due to their …
Synthesis and characterization of Fe3O4-PEG-LAC-chitosan-PEI nanoparticle as a survivin siRNA delivery system
S Arami, MR Rashidi, M Mahdavi… - Human & …, 2017 - journals.sagepub.com
The limited effectiveness of the conventional methods for cancer treatment makes the
researchers to find novel safe and effective therapeutic strategies. One of these strategies is …
researchers to find novel safe and effective therapeutic strategies. One of these strategies is …
Oral delivery of shRNA and siRNA via multifunctional polymeric nanoparticles for synergistic cancer therapy
L Han, C Tang, C Yin - Biomaterials, 2014 - Elsevier
Galactose modified trimethyl chitosan-cysteine (GTC) conjugates with various galactose
grafting densities were developed for oral delivery of Survivin shRNA-expression pDNA …
grafting densities were developed for oral delivery of Survivin shRNA-expression pDNA …
Chitosan-based nanoparticles for survivin targeted siRNA delivery in breast tumor therapy and preventing its metastasis
P Sun, W Huang, M Jin, Q Wang, B Fan… - International journal …, 2016 - Taylor & Francis
Nanoparticle-mediated small interfering RNA (siRNA) delivery is a promising therapeutic
strategy in various cancers. However, it is difficult to deliver degradative siRNA to tumor …
strategy in various cancers. However, it is difficult to deliver degradative siRNA to tumor …
Novel polyacrylate-based cationic nanoparticles for survivin siRNA delivery combined with mitoxantrone for treatment of breast cancer
As a gene delivery method in breast cancer therapy, knocking down the undesired genes in
the cancerous cells would be promising. Inhibitors of Apoptosis Protein (IAP) family genes …
the cancerous cells would be promising. Inhibitors of Apoptosis Protein (IAP) family genes …
Enhancing anti-melanoma outcomes in mice using novel chitooligosaccharide nanoparticles loaded with therapeutic survivin-targeted siRNA
X Liu, L Chen, Y Zhang, X Xin, L Qi, M Jin… - European Journal of …, 2021 - Elsevier
Melanoma anti-tumor therapy remains a challenge. SiRNA-based therapies provide a
powerful means, but limitations remain in its pharmaceutical applications owing to the lack of …
powerful means, but limitations remain in its pharmaceutical applications owing to the lack of …
Downregulation of survivin expression and enhanced chemosensitivity of MCF-7 cells to adriamycin by PDMAE/survivin shRNA complex nanoparticles
Gene silencing mediated by RNA interference (RNAi) presents a promising strategy for gene
therapy. The aim of this work is to evaluate a new gene delivery system for downregulation …
therapy. The aim of this work is to evaluate a new gene delivery system for downregulation …