Simvastatin acts synergistically with ACE inhibitors or amlodipine to decrease oxygen consumption in rat hearts
Statin drugs, which are cholesterol-lowering agents, can upregulate endothelial nitric oxide
synthase (eNOS) in isolated endothelial cells independent of lipid lowering. We investigated …
synthase (eNOS) in isolated endothelial cells independent of lipid lowering. We investigated …
Therapeutic strategies for SARS-CoV-2 acting on ACE-2
A Vitiello, F Ferrara - European Journal of Pharmaceutical …, 2021 - ncbi.nlm.nih.gov
Considering the mechanisms of intracellular penetration of SARS-CoV-2, the significant
related risk factors, changes in ACE-2 concentration during infection, and the complex …
related risk factors, changes in ACE-2 concentration during infection, and the complex …
Which ones, when and why should renin-angiotensin system inhibitors work against COVID-19?
M Montanari, B Canonico, E Nordi, D Vandini… - Advances in Biological …, 2021 - Elsevier
The article describes the possible pathophysiological origin of COVID-19 and the crucial
role of renin-angiotensin system (RAS), providing several “converging” evidence in support …
role of renin-angiotensin system (RAS), providing several “converging” evidence in support …
Angiotensin converting enzyme-2 as therapeutic target in COVID-19
The pandemic of coronavirus disease 2019 (COVID-19) is a global health emergency that
poses a significant threat to world people's health. This outbreak causes major challenges to …
poses a significant threat to world people's health. This outbreak causes major challenges to …
ARB might be superior to ACEI for treatment of hypertensive COVID‐19 patients
HJ Zhao, Y Li, DY Wang… - Journal of Cellular and …, 2021 - Wiley Online Library
The administration of ACEI/ARB (angiotensin‐converting enzyme inhibitors/Angiotension II
receptor blockers) in COVID‐19 (coronavirus disease 2019) patients with hypertension …
receptor blockers) in COVID‐19 (coronavirus disease 2019) patients with hypertension …
The HMG-CoA reductase inhibitor, pravastatin, prevents the development of monocrotaline-induced pulmonary hypertension in the rat through reduction of endothelial …
P Guerard, Z Rakotoniaina, F Goirand… - Naunyn-Schmiedeberg's …, 2006 - Springer
HMG-CoA reductase inhibitors improve endothelial function and exert antiproliferative
effects on vascular smooth muscle cells of systemic vessels. This study was aimed to assess …
effects on vascular smooth muscle cells of systemic vessels. This study was aimed to assess …
Effects of atorvastatin, amlodipine, and their combination on vascular dysfunction in insulin-resistant rats
T Okamura, M Tawa, A Geddawy… - Journal of …, 2014 - jstage.jst.go.jp
Deficiency of tetrahydrobiopterin (BH4) in the vascular tissue contributes to endothelial
dysfunction through reduced eNOS activity and increased superoxide anion (O2−) …
dysfunction through reduced eNOS activity and increased superoxide anion (O2−) …
Sesamin enhances nitric oxide bioactivity in aortas of spontaneously hypertensive rats
X Kong, W Li, L Guo, J Zhang, X Chen… - Therapeutic …, 2015 - journals.sagepub.com
Background: The blood pressure lowering effect of sesamin has been demonstrated to be
associated with the increase in vascular nitric oxide (NO) biological activity by our previous …
associated with the increase in vascular nitric oxide (NO) biological activity by our previous …
Proteomic analysis reveals upregulation of ACE2 (Angiotensin-Converting Enzyme 2), the putative SARS-CoV-2 receptor in pressure–but not volume-overloaded …
DOI: 10.1161/HYPERTENSIONAHA. 120.16261 e42 Hypertension December 2020 found
for AngII receptor blockers (odds ratio, 2.3 [95% CI, 0.3–21.4]; P= 0.453). No relevant effects …
for AngII receptor blockers (odds ratio, 2.3 [95% CI, 0.3–21.4]; P= 0.453). No relevant effects …
Sesamin improves endothelial dysfunction in renovascular hypertensive rats fed with a high-fat, high-sucrose diet
X Kong, J Yang, L Guo, Y Xiong, X Wu, K Huang… - European journal of …, 2009 - Elsevier
The present study was designed to evaluate the possible in vivo protective effects of
sesamin on hypertension and endothelial function in two-kidney, one-clip renovascular …
sesamin on hypertension and endothelial function in two-kidney, one-clip renovascular …