The innate cartilage extracellular matrix is avascular and plays a vital role in innate
chondrocytes. Recapping the crucial components of the extracellular matrix in engineered …

The native cartilage extracellular matrix (ECM) is enriched in sulfated glycosaminoglycans
with important roles in the signaling and phenotype of resident chondrocytes. Recapitulating …

Tissue engineering is a burgeoning research field of regenerative medicine that holds
promise to restore tissues and organs affected by traumatic injury, chronic disorders, age …

Biopolymeric hydrogels that mimic the properties of extracellular matrix have great potential
in promoting cellular migration and proliferation for tissue regeneration. The authors …

Collagen hydrogels are widely used in cartilage tissue engineering for their mimicked
chondrogenic environment. Due to the rapid degradation nature and weak mechanical …

In the past decade, cartilage tissue engineering has arisen as a promising therapeutic
option for degenerative joint diseases, such as osteoarthritis, in the hope of restoring the …

Cartilage is a tension-and load-bearing tissue and has a limited capacity for intrinsic self-
healing. While microfracture and arthroplasty are the conventional methods for cartilage …

Background Cartilage injury and pathological degeneration are reported in millions of
patients globally. Cartilages such as articular hyaline cartilage are characterized by poor self …

Articular cartilage is a load-bearing tissue that lines the surface of bones in diarthrodial
joints. Unfortunately, this avascular tissue has a limited capacity for intrinsic repair …

Cartilage regeneration remains a current challenge with no satisfactory strategy in surgery.
Hydrogels with structurally and biochemically biomimicking characteristics have been …