Purpose: Titanium particle-induced osteolysis is one of the important causes of aseptic
loosening of artificial joints. Previous studies have shown the potential of natural compounds …

Background: Wear debris-induced osteolysis leads to periprosthetic loosening and
subsequent prosthetic failure. Since excessive osteoclast formation is closely implicated in …

Purpose We examined the effects of triptolide on receptor activator of nuclear factor-κB
ligand (RANKL)-induced osteoclast differentiation and on titanium (Ti) particle-induced …

Wear particle-induced aseptic loosening is the most common complication of total joint
arthroplasty (TJA). Excessive osteoclast formation and bone resorptive activation have been …

Peri‐implant osteolysis (PIO) and the subsequent aseptic loosening are the main reasons
for artificial joint implant failure. Existing methods for treating aseptic loosening are far from …

Artificial prosthesis is wildly used in clinical medicine for degenerative disease such as
osteoclast‐related diseases. However, the material wear particles released from the surface …

Wear particles serve a central role in periprosthetic osteolysis, which leads to the aseptic
loosening of prostheses. In the present study a lentiviral vector was constructed to silence …

The present study investigated the role of bidirectional ephrin‑B2/erythropoietin‑producing
human hepatocellular receptor 4 (ephB4) signaling in the regulation of wear particle …

Wearing titanium particle‐induced osteoclastogenesis, accompanied by peri‐implant
osteolysis, is the main cause of long‐term failure of hip prosthesis. Currently, medications …

Wear particles liberated from the surface of prostheses are considered to be main reason for
osteoclast bone resorption and that extensive osteoclastogenesis leads to peri-implant …