Clinical and molecular characteristics of epidermal growth factor receptor exon 20 insertion mutations in non-small-cell lung cancer

D Geng, Q Guo, S Huang, H Zhang, S Guo… - Clinical and Translational …, 2022 - Springer
Objective To evaluate the genomic and immune characteristics of non-small-cell lung cancer
(NSCLC) patients with epidermal growth factor receptor (EGFR) exon 20 insertion (ex20ins) …

[HTML][HTML] Tumor genomics and response to chemotherapy in advanced non-small cell lung cancer with exon 20 insertion epidermal growth factor receptor mutations

Y Wang, J Li, Y Zhou, S Cao, X Ling… - Annals of …, 2020 - ncbi.nlm.nih.gov
Background To characterize the effects of mutation subtypes and concomitant pathogenic
mutations on progression-free survival (PFS) and overall survival (OS) in advanced non …

Effectiveness of treatments for advanced non–small-cell lung cancer with exon 20 insertion epidermal growth factor receptor mutations

JY Wu, CJ Yu, JY Shih - Clinical lung cancer, 2019 - Elsevier
Background Two main categories of epidermal growth factor receptor (EGFR) mutations in
non–small-cell lung cancer (NSCLC) patients are deletions in exon 19 and L858R in exon …

[HTML][HTML] Prevalence of epidermal growth factor receptor exon 20 insertion mutations in non-small-cell lung cancer in Europe: a pragmatic literature review and meta …

S Van Sanden, M Murton, A Bobrowska, N Rahhali… - Targeted Oncology, 2022 - Springer
Background Information on the epidemiology of uncommon EGFR mutations including exon
20 insertions amongst non-small-cell lung cancer (NSCLC) is lacking. Objective The …

[HTML][HTML] Clinical outcomes of EGFR exon 20 insertion mutations in advanced non-small cell lung cancer in Korea

S Byeon, Y Kim, SW Lim, JH Cho, S Park… - Cancer Research and …, 2019 - ncbi.nlm.nih.gov
Purpose Epidermal growth factor receptor (EGFR) exon 20 insertion mutations account for
approximately 4% of all EGFR mutations. Given the rarity of this mutation, its clinical …

EGFR exon 20 insertion mutations in Chinese advanced non-small cell lung cancer patients: molecular heterogeneity and treatment outcome from nationwide real …

G Yang, J Li, H Xu, Y Yang, L Yang, F Xu, B Xia… - Lung Cancer, 2020 - Elsevier
Objectives To describe the treatment patterns and outcomes of Chinese non-small cell lung
cancer (NSCLC) patients with epidermal growth factor receptor (EGFR) exon 20 insertion …

[HTML][HTML] Sensitivity to Immune Checkpoint Blockade in Advanced Non-Small Cell Lung Cancer Patients with EGFR Exon 20 Insertion Mutations

G Metro, S Baglivo, G Bellezza, M Mandarano, A Gili… - Genes, 2021 - mdpi.com
Besides platinum-based chemotherapy, no established treatment option exists for advanced
non-small-cell lung cancer (NSCLC) patients with EGFR exon 20 (Ex20ins) insertion …

[HTML][HTML] A multicenter-retrospective study of non-small-cell lung carcinoma harboring uncommon epidermal growth factor receptor (EGFR) mutations: different …

Y Chen, J Xu, L Zhang, Y Song, W Wen… - Translational Lung …, 2022 - ncbi.nlm.nih.gov
Background The aim of this study was to investigate the clinical features,
immunohistochemistry (IHC), compound mutation, and prognosis of patients with non-small …

EGFR Exon 20 Insertion Mutations: Clinicopathological Characteristics and Treatment Outcomes in Advanced Non–Small Cell Lung Cancer

JL Leal, M Alexander, M Itchins, GM Wright, S Kao… - Clinical lung cancer, 2021 - Elsevier
Background Epidermal growth factor receptor gene (EGFR) exon 20 insertion (ex20-ins)
mutations are an uncommon and heterogeneous group of non–small cell lung cancers …

[HTML][HTML] Clinical characteristics of advanced non-small cell lung cancer patients with EGFR exon 20 insertions

C Morita, T Yoshida, M Shirasawa, K Masuda… - Scientific reports, 2021 - nature.com
Epidermal growth factor receptor (EGFR) exon 20 insertion mutations (Exon20ins) account
for 4–12% of all EGFR mutations in non-small cell lung cancer (NSCLC) patients. Data on …