Background Cholinergic neurons utilize choline (Ch) to synthetize acetylcholine (ACh) and
contain a high-affinity Ch transporter, Ch acetyltransferase (ChAT), ACh receptors, and …

A number of observations support the hypothesis that a central deficit in acetylcholine (ACh)
may be responsible for the initiation of Alzheimer's disease (AD). For example, cholinergic …

Cholinesterase inhibitors are commonly used to improve cognition and treat psychosis and
other behavioral symptoms in Alzheimer's disease, Parkinson's disease, and other …

An impaired central cholinergic system is at least partly involved in Alzheimer's disease (AD)
pathogenesis, with cholinergic markers such as acetylcholinesterase (AChE) activity and …

Alzheimer's disease (AD) is a progressive disease with early degeneration of the central
cholinergic neurons. Currently, three of four AD drugs act by inhibiting the acetylcholine …

Acetylcholine (ACh) has been the first molecule to be identified as neurotransmitter. The
cholinergic and cholinoceptive areas, both in central and peripheral nervous system, have …

Acetylcholine (ACh) is a neurotransmitter widely diffused in central, peripheral, autonomic
and enteric nervous system. This paper has reviewed the main mechanisms of ACh …

Acetylcholine (ACh) has a crucial role in the peripheral and central nervous systems. The
enzyme choline acetyltransferase (ChAT) is responsible for synthesizing ACh from acetyl …

Cholinergic dysfunction is known as a hallmark feature of Alzheimer's disease (AD).
Measurement of endogenous acetylcholine (ACh) in specific brain regions is important in …

Acetylcholine (ACh) is ubiquitously present in the nervous system and has been involved in
the regulation of various brain functions. By modulating synaptic transmission and promoting …