Dosing time-dependency of pharmacokinetics (or chronopharmacokinetics) has been long
recognized. Studies in recent years have revealed that daily rhythmicity in expression of …

Dependence of pharmacokinetics and drug effects (efficacy and toxicity) on dosing time has
long been recognized. However, significant progress has only recently been made in our …

Dosing time accounts for a large variability in efficacy and/or toxicity for many drugs.
Therefore, chronotherapy has been shown to effectively improve drug efficacy and to reduce …

Metabolism and transport of many drugs oscillate with times of the day (solar time), resulting
in circadian time-dependent drug exposure and pharmacokinetics. Time-dependent …

Dependence of drug metabolism on dosing time has long been recognized. However, only
recently are the underlying mechanisms for circadian drug metabolism being clarified …

Pharmacokinetics deals with the in vivo fate of or disposition processes of the drug (ie how
the body does to the drug) that determine drug exposure and therefore pharmacological …

Most mammalian physiology is orchestrated by the circadian clock, including drug transport
and metabolism. As a result, efficacy and toxicity of many drugs are influenced by the timing …

The importance of drug dosing time in pharmacokinetics, pharmacodynamics, and toxicity is
receiving increasing attention from the scientific community. In spite of mounting evidence …

Introduction The 24-hour variations in drug absorption, distribution, metabolism, and
elimination, collectively known as pharmacokinetics, are fundamentally influenced by …

In recent years, the relevance of the circadian clock in physiology, pathology and
therapeutics has increased exponentially, as evidenced by the 2017 Nobel Prize in …