The 21-amino acid peptide endothelin-1 (ET-1) is the predominant isoform of the endothelin
peptide family, which includes ET-2, ET-3, and ET-4. It exerts various biological effects …

Cardiovascular disease is a major contributor to global morbidity and mortality and is the
common end point of many chronic diseases. The endothelins comprise three structurally …

The endothelin family of peptides are extremely potent endogenous vasoconstrictor and
pressor agents. Of the 3 isoforms, endothelin-1 is the major isoform produced by the …

The endothelin (ET) system consists of 3 ET isopeptides, several isoforms of activating
peptidases, and 2 G-protein-coupled receptors, ETA and ETB, that are linked to multiple …

Endothelins are powerful vasoconstrictor peptides that also play numerous other roles. The
endothelin (ET) family consists of three peptides produced by a variety of tissues. Endothelin …

Endothelin (ET)-1, an endothelium-derived peptide, is the most potent vasoconstrictor agent
described to date. ET-1 also has positive inotropic and chronotropic effects in the heart and …

Endothelins (ET) are a family of peptides with potent biological properties. Endothelial cells
produce exclusively ET-1 while other tissues produce ET-2 and ET-3. The production of ET …

The endothelin (ET) system consists of three peptide ligands (ET-1, ET-2 and ET-3) and two
G-protein-coupled receptors, ETA and ETB. In the cardiovascular system, ETs, particularly …

Endothelin receptor antagonists (ERAs) have been developed to block the effects of
endothelin-1 (ET-1) in a variety of cardiovascular conditions. ET-1 is a powerful …

Abstract Endothelin (ET)-1 is a potent vasoconstrictor peptide originally isolated from
endothelial cells. Its production is stimulated in a variety of different cell types under the …