Objective SIRT1 has been proposed to be a key signaling node linking changes in energy
metabolism to transcriptional adaptations. Although SIRT1 overexpression is protective …

Objective Available treatment for obesity and type 2 diabetes mellitus (T2DM) is suboptimal.
Thus, identifying novel molecular target (s) exerting protective effects against these …

SIRT1 is a prominent member of a family of NAD+-dependent enzymes and affects a variety
of cellular functions ranging from gene silencing, regulation of the cell cycle and apoptosis …

Adipose tissue plays an important role in storing excess nutrients and preventing ectopic
lipid accumulation in other organs. Obesity leads to excess lipid storage in adipocytes …

Insulin resistance is often characterized as the most critical factor contributing to the
development of type 2 diabetes. SIRT1 has been reported to be involved in the processes of …

The unique thermogenic capacity of brown adipocyte makes it an attractive target for
antiobesity treatments. Several epigenetic regulators can control brown adipocyte …

Upon nutrient stimulation, pre-adipocytes undergo differentiation to transform into mature
adipocytes capable of storing nutrients as fat. We profiled cellular metabolite consumption to …

Objective Recent studies have revealed that SIRT1 gain‐of‐function could promote adipose
tissue browning for the adaptive thermogenesis under normal diet. This study investigated …

Brown adipose tissue (BAT) activity plays a key role in regulating systemic energy. The
activation of BAT results in increased energy expenditure, making this tissue an attractive …

The NAD+-dependent deacetylase SIRT2 is unique amongst sirtuins as it is effective in the
cytosol, as well as the mitochondria. Defining the role of cytosolic acetylation state in specific …