Adiposity and the risk of dementia: mediating effects from inflammation and lipid levels

IK Karlsson, Y Zhan, Y Wang, X Li, J Jylhävä… - European Journal of …, 2022 - Springer
While midlife adiposity is a risk factor for dementia, adiposity in late-life appears to be
associated with lower risk. What drives the associations is poorly understood, especially the …

Association of life course adiposity with risk of incident dementia: a prospective cohort study of 322,336 participants

YT Deng, YZ Li, SY Huang, YN Ou, W Zhang… - Molecular …, 2022 - nature.com
Cohort studies report inconsistent associations between body mass index (BMI) and all-
cause incident dementia. Furthermore, evidence on fat distribution and body composition …

Adiposity in the older population and the risk of dementia: The Rotterdam Study

SS Mooldijk, TOE de Crom, MK Ikram… - Alzheimer's & …, 2023 - Wiley Online Library
Introduction We determined associations of total and regional adiposity with incident
dementia among older adults. Methods Within the population‐based Rotterdam Study …

Body adiposity in late life and risk of dementia or cognitive impairment in a longitudinal community-based study

NA West, MN Haan - Journals of Gerontology Series A …, 2009 - academic.oup.com
Background The association between body adiposity at older ages and the development of
cognitive impairment is unclear. Methods The association of body mass index (BMI) and …

The epidemiology of adiposity and dementia

RA Whitmer - Current Alzheimer Research, 2007 - ingentaconnect.com
Adipose tissue is the largest endocrine gland in the body, yet only recently has its role in
neurodegenerative disease been considered. Prospective population level evidence has …

Body adiposity in later life and the incidence of dementia: the health in men study

BD Power, H Alfonso, L Flicker, GJ Hankey, BB Yeap… - PloS one, 2011 - journals.plos.org
Objective To determine if adiposity in later life increases dementia hazard. Methods Cohort
study of 12,047 men aged 65–84 years living in Perth, Australia. Adiposity exposures were …

High adiposity: risk factor for dementia and Alzheimer's disease?

DR Gustafson, JA Luchsinger - Alzheimer's Research & Therapy, 2013 - Springer
Higher levels of total and central adiposity, measured as higher body mass index (BMI)(in
kilograms per square meter), waist circumference, or waist-to-hip ratio, have been …

A 10-year follow-up of adiposity and dementia in Swedish adults aged 70 years and older

IAC Arnoldussen, V Sundh, K Bäckman… - Journal of …, 2018 - content.iospress.com
Background: Adiposity measured in mid-or late-life and estimated using anthropometric
measures such as body mass index (BMI) and waist-to-hip ratio (WHR), or metabolic …

Associations of body composition with incident dementia in older adults: Cardiovascular Health Study‐Cognition Study

C Cui, RH Mackey, CE Shaaban… - Alzheimer's & …, 2020 - Wiley Online Library
Introduction A body of literature reported associations between late‐life general adiposity
measures (eg, body mass index) and dementia. Little is known about the association of late …

Increased visceral adipose tissue rather than BMI as a risk factor for dementia

E Cereda, V Sansone, G Meola… - Age and ageing, 2007 - academic.oup.com
In addition to the association between overweight/obesity and cardiovascular disorders, with
the presence of a vascular burden as a cofactor, recent studies have particularly focused on …