Population pharmacokinetics of esketamine nasal spray and its metabolite noresketamine in healthy subjects and patients with treatment-resistant depression
C Perez-Ruixo, S Rossenu, P Zannikos, P Nandy… - Clinical …, 2021 - Springer
Background Esketamine nasal spray is approved for treatment-resistant depression.
Objective The objective of this study was to characterize the pharmacokinetics of esketamine …
Objective The objective of this study was to characterize the pharmacokinetics of esketamine …
[HTML][HTML] Intranasal esketamine (SpravatoTM) for use in treatment-resistant depression in conjunction with an oral antidepressant
R Bahr, A Lopez, JA Rey - Pharmacy and Therapeutics, 2019 - ncbi.nlm.nih.gov
Major depressive disorder (MDD) affects more than 16 million adults each year in the United
States. 1 The incomplete response that many persons experience with current …
States. 1 The incomplete response that many persons experience with current …
Esketamine for treatment resistant depression: a trick of smoke and mirrors?
In March 2019, the US Food and Drug Administration (FDA) approved a nasal spray
formulation of esketamine for the treatment of resistant depression in adults. Esketamine is …
formulation of esketamine for the treatment of resistant depression in adults. Esketamine is …
[HTML][HTML] Predicting outcome with Intranasal Esketamine treatment: A machine-learning, three-month study in Treatment-Resistant Depression (ESK-LEARNING)
Abstract Treatment-resistant depression (TRD) represents a severe clinical condition with
high social and economic costs. Esketamine Nasal Spray (ESK-NS) has recently been …
high social and economic costs. Esketamine Nasal Spray (ESK-NS) has recently been …
A word to the wise about intranasal esketamine
AF Schatzberg - American Journal of Psychiatry, 2019 - Am Psychiatric Assoc
Rarely has there been so much anticipation for a new antidepressant as has been seen for
intranasal esketamine, the putatively more effective enantiomer of ketamine. This reflects the …
intranasal esketamine, the putatively more effective enantiomer of ketamine. This reflects the …
[HTML][HTML] Ketamine for the treatment of major depression: a systematic review and meta-analysis
Background Intranasal esketamine has received regulatory approvals for the treatment of
depression. Recently a large trial of repeated dose racemic ketamine also demonstrated …
depression. Recently a large trial of repeated dose racemic ketamine also demonstrated …