Hypoxia plays a fundamental role in the pathophysiology of common causes of mortality,
including ischemic heart disease, stroke, cancer, chronic lung disease, and congestive heart …

Abstract Hypoxia-inducible factor 1 (HIF-1) activates transcription of genes encoding
proteins that mediate adaptive responses to reduced oxygen availability. The HIF-1β subunit …

All organisms can sense O2 concentration and respond to hypoxia with adaptive changes in
gene expression. The large body size of mammals necessitates the development of multiple …

Hypoxia-inducible factor 1 (HIF-1) is a basic-helix-loop-helix transcription factor that plays
essential roles in mammalian development and physiology. HIF-1 is a heterodimer …

Sensing and responding to fluxes in oxygen tension is perhaps the single most important
variable in physiology, and animal tissues have developed a number of essential …

The increase in body size of humans and other vertebrates requires a physiological
infrastructure to provide adequate delivery of oxygen to tissues and cells to maintain oxygen …

Hypoxia-inducible factor 1 (HIF-l) accumulates in the nuclei of mammalian cells exposed to
reduced O2 tension in a time-and O2 concentration-dependent manner. HIF-1 plays an …

Hypoxia, or lowered physiological oxygenation, is a component of many diseases. The
response to decreased oxygen tensions is also an essential aspect of normal development …

Summary Hypoxia‐inducible factor 1 (HIF‐1) is a critical mediator of physiological
responses to acute and chronic hypoxia. First, HIF‐1 is required for the development of the …

Hypoxia-inducible factor (HIF) is a transcriptional activator that coordinates adaptive
responses to hypoxia. An increased activity is recognized in the majority of clinical relevant …