Despite that cyclosporine-A (CsA) is a widely used immunosuppressive drug, its nephrotoxic
effect limits its long-term administration. Herein we tried to investigate its renal effect on …

Nitric oxide modulates vascular endothelial growth factor and receptors in chronic
cyclosporine nephrotoxicity. Background Vascular endothelial growth factor (VEGF) is …

Background Clinically, chronic nephrotoxicity may lead to renal functional impairment and
progress to end stage renal failure. The renoprotective effect of a flavonoid naringin (NG) …

Cyclosporine A (CsA), a well-known immunosuppressive drug, has been prescribed after
organ transplantation and in a variety of disorders with an immunological origin …

Aims The nephrotoxicity of cyclosporine A (CsA) limits its use as an immunosuppressant.
Wnt/β-catenin signaling is involved in the pathogenesis of both acute and chronic kidney …

Abstract Background Cyclosporine A (CsA)-induced nephrotoxicity is a challenging problem
complicating its chronic use in a large array of autoimmune diseases, as well as in organ …

Cyclosporine A (CsA) is a potent and effective immunosuppressive agent, but its use is
frequently accompanied by severe renal toxicity. The causes for the nephrotoxicity of CsA …

Cyclosporine A (CsA) is widely employed in the management of solid organ transplantation
but often brought occurrence of nephrotoxicity. The present study investigates its potential …

Background: Cyclosporine A (CsA) is an immunosuppressant with therapeutic indications in
various immunological diseases; however, its use is associated with chronic nephropathy …

The aim of this study was to investigate effect of nitric oxide (NO) modulation on possible
nephroprotective mechanisms of nebivolol (NEB) in cyclosporine A (CsA)-induced …