Nilotinib is a known tyrosine kinase inhibitor that has been approved for treatment of
leukemia. The possible protective effect of nilotinib on cyclosporine A-induced nephropathy …

The aim of this study was to evaluate the influence of cyclosporine A (CsA) on glomerular
growth and the effect of mizoribine (MZR) and losartan (LSAR) on CsA-induced nephropathy …

Aims Cyclophosphamide (CTX) is an effective anti-tumor and immunosuppressive agent, but
it induces nephrotoxicity in clinical applications. The present study aimed to evaluate the …

Oxidative stress is involved in the pathogenesis of a number of diseases including
hypertension and renal failure. There is enhanced expression of nicotinamide adenine …

Oxidative stress induced by long‐term cyclosporine A (CsA) administration is a major cause
of chronic nephrotoxicity, which is characterized by tubular atrophy, tubular cell apoptosis …

Background Nuclear factor erythroid-2-related factor-2 (Nrf2) is known to protect against
tissue injury by orchestrating antioxidant and detoxification responses to oxidative stress …

Cyclosporin A (CsA) is the prototype of immunosuppressant drugs that have revolutionized
the management of all transplantation and autoimmune diseases. Side effects of CsA mainly …

Background: The exact mechanism of cyclosporine (CsA) nephrotoxicity has not been
clarified. In this study, we investigated the effect of pharmacological doses of CsA on the …

Abstract Background Cyclosporine-A (CsA) is an immunosuppressant indicated for various
immunological diseases; however, it can induce chronic kidney injury. Oxidative stress and …

Therapeutic benefit of spironolactone in experimental chronic cyclosporine A nephrotoxicity.
Background Cyclosporine A (CsA) is an immunosuppressive drug used to prevent tissue …