Radiosensitivity enhancement by Celecoxib, a cyclooxygenase (COX)-2 selective inhibitor, via COX-2–dependent cell cycle regulation on human cancer cells …
YK Shin, JS Park, HS Kim, HJ Jun, GE Kim, CO Suh… - Cancer research, 2005 - AACR
To characterize the radiation-enhancing effects on human cancer cells and underlying
mechanisms of celecoxib, a cyclooxygenase (COX)-2 selective inhibitor, and to ascertain …
mechanisms of celecoxib, a cyclooxygenase (COX)-2 selective inhibitor, and to ascertain …
Combination of radiation and celebrex (celecoxib) reduce mammary and lung tumor growth
W Liu, Y Chen, W Wang, P Keng… - American journal of …, 2003 - journals.lww.com
Abstract The selective cyclooxygenase (COX)-2 inhibitor, celecoxib, alone and in
combination with radiation was investigated in vitro and in vivo. Murine mammary tumor line …
combination with radiation was investigated in vitro and in vivo. Murine mammary tumor line …
Potentiation of tumor response to radiation or chemoradiation by selective cyclooxygenase-2 enzyme inhibitors
E Nakata, KA Mason, N Hunter, A Husain… - International Journal of …, 2004 - Elsevier
Cyclooxygenase-2 (COX-2) is an enzyme expressed primarily in pathologic states, such as
inflammatory disorders and cancer, where it mediates prostaglandin production. Its …
inflammatory disorders and cancer, where it mediates prostaglandin production. Its …
Celecoxib enhances the sensitivity of non-small-cell lung cancer cells to radiation-induced apoptosis through downregulation of the Akt/mTOR signaling pathway and …
P Zhang, D He, E Song, M Jiang, Y Song - PLoS One, 2019 - journals.plos.org
The current study aimed to identify the radiosensitizing effect of celecoxib, a selective
cyclooxygenase-2 (COX-2) inhibitor, in combination with radiotherapy in non-small-cell lung …
cyclooxygenase-2 (COX-2) inhibitor, in combination with radiotherapy in non-small-cell lung …
Celecoxib induced tumor cell radiosensitization by inhibiting radiation induced nuclear EGFR transport and DNA-repair: a COX-2 independent mechanism
KH Dittmann, C Mayer, PA Ohneseit, U Raju… - International Journal of …, 2008 - Elsevier
PURPOSE: The purpose of the study was to elucidate the molecular mechanisms mediating
radiosensitization of human tumor cells by the selective cyclooxygenase (COX)-2 inhibitor …
radiosensitization of human tumor cells by the selective cyclooxygenase (COX)-2 inhibitor …
Inhibition of cyclooxygenase-2 activity by celecoxib does not lead to radiosensitization of human prostate cancer cells in vitro
PA Ohneseit, G Krebiehl, K Dittmann… - Radiotherapy and …, 2007 - Elsevier
PURPOSE: To evaluate the potential radiosensitizing effect of the specific COX-2 inhibitor
celecoxib (Celebrex®) on prostate carcinoma cells in vitro. MATERIALS AND METHODS …
celecoxib (Celebrex®) on prostate carcinoma cells in vitro. MATERIALS AND METHODS …
[HTML][HTML] Celecoxib enhances radiosensitivity via induction of G2-M phase arrest and apoptosis in nasopharyngeal carcinoma
Background: Previous work has proposed that celecoxib may be able to enhance the effects
of radiotherapy. However, the underlying mechanism of this activity has not yet been …
of radiotherapy. However, the underlying mechanism of this activity has not yet been …
Celecoxib reduces skin damage after radiation: selective reduction of chemokine and receptor mRNA expression in irradiated skin but not in irradiated mammary …
L Liang, D Hu, W Liu, JP Williams… - American journal of …, 2003 - journals.lww.com
Inflammatory cytokine and chemokine production is mediated, at least in part, by
prostaglandin E (PGE2). Cyclooxygenases, COX-1 and COX-2, are two key enzymes in the …
prostaglandin E (PGE2). Cyclooxygenases, COX-1 and COX-2, are two key enzymes in the …
Synergy between Celecoxib and Radiotherapy Results from Inhibition of Cyclooxygenase-2-Derived Prostaglandin E2, a Survival Factor for Tumor and Associated …
TW Davis, JM O'Neal, MD Pagel, BS Zweifel, PP Mehta… - Cancer research, 2004 - AACR
Previous work has demonstrated that selective cyclooxygenase-2 (COX-2) inhibitors can act
synergistically with radiotherapy to improve tumor debulking and control in preclinical …
synergistically with radiotherapy to improve tumor debulking and control in preclinical …
Inhibition of DNA repair as a mechanism of enhanced radioresponse of head and neck carcinoma cells by a selective cyclooxygenase-2 inhibitor, celecoxib
U Raju, H Ariga, K Dittmann, E Nakata, KK Ang… - International Journal of …, 2005 - Elsevier
Purpose: Previously, we reported that inhibitors of cyclooxygenase-2 (COX-2) enzyme
enhanced murine and human tumor cell response to radiation in vitro and in vivo. However …
enhanced murine and human tumor cell response to radiation in vitro and in vivo. However …