Abstract Purpose: The Calvert formula is a widely applied algorithm for the a priori dosing of
carboplatin based on patients glomerular filtration rate (GFR) as accurately measured using …

Carboplatin is a chemotherapeutic agent frequently used in the treatment of various
malignancies. An individual dosing strategy has been recommended to yield the most …

Carboplatin is a platinum-based anticancer drug that has been long used to treat many
types of solid cancer. Because the clearance of carboplatin strongly correlates with the …

Background: Carboplatin is used in treating many types of cancer. Because renal excretion
is the major variable determining the pharmacokinetics of this drug, a dosing formula based …

The aim was to compare doses of carboplatin calculated using the Calvert formula and
Chatelut formula and also to compare doses calculated using Calvert formula, modified with …

Purpose: Carboplatin is frequently dosed to achieve a desired area under the plasma
concentration-time curve (AUC) by using the Calvert or Chatelut equations to estimate …

The use of the Calvert formula to calculate carboplatin doses allows clinicians to achieve the
appropriate carboplatin area under the concentration (AUC) curve. Thrombocytopenia is the …

Abstract Purpose The Calvert formula was derived from the study among patients with
glomerular filtration rates (GFRs) of 33–135 ml/min, and it remains unclear whether the …

Creatinine clearance (Ccr) is widely used as a practical substitute for glomerular filtration
rate (GFR) in the Calvert formula: carboplatin dose (mg)= target area under the …

Purpose While doses of carboplatin are mostly individualized according to the Calvert
equation based on estimated Glomerular Filtration Rate (eGFR), there is still uncertainty …