Regulatory T cells: the many faces of Foxp3
Regulatory T (Treg) cells expressing the transcription factor forkhead box P3 (Foxp3) play a
requisite role in the maintenance of immunological homeostasis and prevention of …
requisite role in the maintenance of immunological homeostasis and prevention of …
Functional reprogramming of regulatory T cells in the absence of Foxp3
Regulatory T cells (Treg cells) deficient in the transcription factor Foxp3 lack suppressor
function and manifest an effector T (Teff) cell–like phenotype. We demonstrate that Foxp3 …
function and manifest an effector T (Teff) cell–like phenotype. We demonstrate that Foxp3 …
The regulation and differentiation of regulatory T cells and their dysfunction in autoimmune diseases
The discovery of FOXP3+ regulatory T (Treg) cells as a distinct cell lineage with a central
role in regulating immune responses provided a deeper understanding of self-tolerance …
role in regulating immune responses provided a deeper understanding of self-tolerance …
Regulatory T cells: regulation of identity and function
T regulatory cells suppress a variety of immune responses to self-antigens and play a role in
peripheral tolerance maintenance by limiting autoimmune disorders, and other pathological …
peripheral tolerance maintenance by limiting autoimmune disorders, and other pathological …
T regulatory cell biology in health and disease
FJ Alroqi, TA Chatila - Current allergy and asthma reports, 2016 - Springer
Regulatory T (Treg) cells that express the transcription factor forkhead box protein P3
(FOXP3) play an essential role in enforcing immune tolerance to self tissues, regulating host …
(FOXP3) play an essential role in enforcing immune tolerance to self tissues, regulating host …
Regulatory T cells and human disease
S Sakaguchi, N Mikami, JB Wing… - Annual review of …, 2020 - annualreviews.org
Naturally occurring CD4+ regulatory T cells (Tregs), which specifically express the
transcription factor FoxP3 in the nucleus and CD25 and CTLA-4 on the cell surface, are a …
transcription factor FoxP3 in the nucleus and CD25 and CTLA-4 on the cell surface, are a …
Mechanisms of human FoxP3+ Treg cell development and function in health and disease
M Attias, T Al-Aubodah… - Clinical & experimental …, 2019 - academic.oup.com
Regulatory T (Treg) cells represent an essential component of peripheral tolerance. Given
their potently immunosuppressive functions that is orchestrated by the lineage-defining …
their potently immunosuppressive functions that is orchestrated by the lineage-defining …
Continuous requirement for the TCR in regulatory T cell function
Foxp3+ regulatory T cells (Treg cells) maintain immunological tolerance, and their deficiency
results in fatal multiorgan autoimmunity. Although heightened signaling via the T cell antigen …
results in fatal multiorgan autoimmunity. Although heightened signaling via the T cell antigen …
[HTML][HTML] Development and maintenance of regulatory T cells
N Ohkura, Y Kitagawa, S Sakaguchi - Immunity, 2013 - cell.com
Regulatory T (Treg) cells are a developmentally and functionally distinct T cell
subpopulation that is engaged in sustaining immunological self-tolerance and homeostasis …
subpopulation that is engaged in sustaining immunological self-tolerance and homeostasis …
Role of regulatory T cells and FOXP3 in human diseases
R Bacchetta, E Gambineri, MG Roncarolo - Journal of Allergy and Clinical …, 2007 - Elsevier
Immune regulation and tolerance are specific functions of the immune system, meaning at
prevention or limitation of effector immune responses against inner and external insults …
prevention or limitation of effector immune responses against inner and external insults …