A major theme of addiction research has focused on the neural substrates of individual
differences in the risk for addiction; however, little is known about how vulnerable …

Cocaine produces its reinforcing effects primarily by inhibiting the dopamine transporter
(DAT) at the level of presynaptic terminals and increasing extracellular levels of dopamine …

Both humans and animals exhibit marked individual differences in cocaine responsiveness.
By using the median split of cocaine-induced locomotor activity, we have classified outbred …

The reinforcing efficacy of cocaine is largely determined by its capacity to inhibit the
dopamine transporter (DAT), and emerging evidence suggests that differences in cocaine …

Cocaine elevates dopamine (DA) in the nucleus accumbens (NAc) by blocking the uptake of
DA through the DA transporter (DAT). It is commonly believed that the reinforcing properties …

Cocaine is a commonly abused central nervous system stimulant that enhances dopamine
(DA) neurotransmission through its ability to block dopamine transporters (DAT s). Recent …

Adult outbred Sprague–Dawley rats can be classified as either low or high cocaine
responders (LCRs or HCRs, respectively). Importantly, LCRs and HCRs are distinguished …

Background Subjective effects of cocaine are mediated primarily by dopamine (DA)
transporter (DAT) blockade. The present study assessed the hypothesis that different DAT …

Although the dopamine transporter (DAT) is the primary site of action for cocaine, and the
dopamine system is known to mediate the reinforcing effects of cocaine, the dopaminergic …

Rationale Behavioural sensitization is a long lasting phenomenon that has been proposed
to be involved in drug addiction. Although the expression of cocaine-induced sensitization …