Cocaine abuse disrupts dopamine system function, and reduces cocaine inhibition of the
dopamine transporter (DAT), which results in tolerance. Although tolerance is a hallmark of …

Variations in the expression levels of the dopamine transporter (DAT) can influence
responsiveness to psychostimulant drugs like cocaine. To better understand this …

BACKGROUND:: Psychomotor stimulant drugs such as cocaine and amphetamine activate
brain dopamine (DA) neurotransmission and support self-administration in humans and …

In vivo microdialysis was used to characterize basal dopamine (DA) dynamics and cocaine-
evoked DA levels in the striatum of 129/Sv-ter, C57BL/6J, DBA/2J, and Swiss-Webster mice …

J. Neurochem.(2011) 119, 332–341. Abstract Repeated exposure to cocaine progressively
increases drug‐induced locomotor activity, which is termed behavioral sensitization …

Drug addiction is a neuropsychiatric disorder marked by escalating drug use. Dopamine
neurotransmission in the ventromedial striatum (VMS) mediates acute reinforcing effects of …

Tolerance to the neurochemical and psychoactive effects of cocaine after repeated use is a
hallmark of cocaine addiction in humans. However, comprehensive studies on tolerance to …

Dopamine (DA) and the DA transporter (DAT) play important roles in psychomotor stimulant
behavioral activation and reward. By understanding how DAT activity is regulated, we will …

We have previously shown that brief (1 h) and extended (6 h) daily access to IV cocaine self-
administration produce different behavioral and neural consequences following 2 weeks of …

Dopamine signaling in nucleus accumbens is essential for cocaine reward. Interestingly,
imaging studies have reported blunted dopamine increases in striatum (assessed as …