In this issue of Neuropsychopharmacology there are nine articles describing important
discoveries that advance our understanding of the neurobiology of cocaine addiction. That …

Extensive evidence suggests that the reinforcing effects of cocaine involve inhibition of
dopamine transporters (DAT) and subsequent increases in dopamine (DA) levels in the …

Drug addiction is associated with altered dopamine (DA) neurotransmission in the basal
ganglia. We have previously shown that chronic stimulation of the dopamine D2 receptor …

Although dysregulation within the dopamine (DA) system is a hallmark feature of chronic
cocaine exposure, the question of whether these alterations persist into abstinence remains …

Dopamine (DA) responses in the nucleus accumbens (NAcc) and dorsal striatum (DS) are
commonly associated with different aspects of cocaine effects. Enhanced NAcc DA has been …

The striatum, both dorsal and ventral, is strongly implicated in substance use disorder.
Chronic consumption of abused substances, such as cocaine, can cause an oversaturation …

Typical and atypical dopamine uptake inhibitors (DUIs) prefer distinct conformations of the
dopamine transporter (DAT) to form ligand-transporter complexes, resulting in markedly …

Cocaine has actions in the peripheral nervous system that reliably precede—and thus
predict—its soon-to-follow central rewarding effects. In cocaine-experienced animals, the …

Previous studies have demonstrated that cocaine use alters availability of brain dopamine
D2 receptors (D2R) and transporters (DAT). The present study examined the effects of low …

BACKGROUND: Addictive drugs produce neuroadaptations in dopamine neurons of the
ventral tegmental area. It is unknown if individual differences in these neuroadaptive …