Mitochondria are highly involved in the metastasis of cancer cells. However, low
permeability of mitochondria impedes the entry of anti‐cancer drugs. Here, a self …

Mitochondria play a central role in cancer progression and tumor metastasis, and
nanomedicines targeting mitochondria have emerged as a promising strategy for tumor …

Nanomedicines have been designed and developed to deliver anticancer drugs or exert
anticancer therapy more selectively to tumor sites. Recent investigations have gone beyond …

Mitochondria are critical subcellular organelles that produce most of the adenosine
triphosphate (ATP) as the energy source for most eukaryotic cells. Moreover, recent findings …

Effective targeting of mitochondria has emerged as an alternative strategy in cancer
chemotherapy. However, considering mitochondria's crucial role in cellular energetics …

Highlights•Dysregulation of mitochondrial metabolism is a hallmark of cancer development.•
Nanoparticles (NPs) enable the efficient and targeted delivery of mitochondrial agents.•NPs …

Any variation in normal cellular function results in mitochondrial dysregulation that occurs in
several diseases, including cancer. Such processes as oxidative stress, metabolism …

Mitochondria-targeting damage has become a popular therapeutic option for tumor
metastasis; however, its efficacy is limited by the adaptive rescue capacity of nuclei. There is …

Delivering traditional DNA-damaging anticancer drugs into mitochondria to damage
mitochondria is a promising chemotherapy strategy. The impermeability of this mitochondrial …

Mitochondria play critical roles in the regulation of the proliferation and apoptosis of
cancerous cells. Nanosystems for targeted delivery of cargos to mitochondria for cancer …