It is well admitted that the link between chronic inflammation and cancer involves cytokines
and mediators of inflammatory pathways, which act during the different steps of …

Abstract Cyclooxygenase‐2 (COX‐2) is the inducible isoform of cyclooxygenase, the
enzyme that catalyzes the rate‐limiting step in prostaglandin synthesis from arachidonic …

Prostaglandins and thromboxane are lipid signaling molecules deriving from arachidonic
acid by the action of the cyclooxygenase isoenzymes COX-1 and COX-2. The role of …

Despite recent improvements in chemotherapy and radiation therapy in cancer management
with the addition of biological agents, novel treatment approaches are needed to further …

Abstract Cyclooxygenase‐2 (COX‐2) is frequently expressed in many types of cancers
exerting a pleiotropic and multifaceted role in genesis or promotion of carcinogenesis and …

Epidemiologic studies have documented a 40–50% reduction in incidence of colorectal
cancer in individuals taking nonsteroidal antiinflammatory drugs (NSAIDs). Since NSAIDs …

Cyclooxygenase-2 (Cox-2) is an inducible enzyme involved in the conversion of arachidonic
acid to prostaglandin and other eicosanoids. Molecular pathology studies have revealed …

The present paper reviews current concepts on the role of cyclooxygenase (COX) in the
development of malignant tumors. An inducible isoform of cyclooxygenase is expressed in …

Compelling experimental and clinical evidence supports the notion that cyclooxygenase-2,
the inducible isoform of cyclooxygenase, plays a crucial role in oncogenesis. Clinical and …

Cyclooxygenase (COX)-2 levels are elevated in several types of human cancer tissues.
Nonselective nonsteroidal anti-inflammatory drugs (NSAIDs) inhibit both the COX-1 and …