Abstract Cyclooxygenase-2 (COX-2), an inducible form of the enzyme that catalyzes the first
step in the synthesis of prostanoids, is associated with inflammatory diseases and …

Several types of human tumors overexpress cyclooxygenase (COX)-2 but not COX-1, and
gene knockout transfection experiments demonstrate a central role of COX-2 in …

In recent years, a combination of two demographic phenomena, an increase in the number
of older people in the population and an increase in the incidence of lung cancer with age …

Preclinical studies suggest that cyclooxygenase (COX)-2 may be involved in the molecular
pathogenesis of some types of lung cancer. Most of the available studies point to its …

Increased prostaglandin (PG) production is associated with many inflammatory
pathophysiological conditions; it is derived from arachidonic acid by either of two enzymes …

Abstract Cyclooxygenase-2 (COX-2), the enzyme that converts arachidonic acid to
prostaglandin H 2, is expressed in normal brain and kidney, activated macrophages …

Abstract Cyclooxygenase (COX)—2, an inducible isoform of cyclooxygenases, regulates the
rapid production of high levels of prostaglandins during inflammation. Cyclooxygenase-2 is …

Abstract The cyclooxygenase-2 (COX-2) gene encodes an inducible enzyme that converts
arachidonic acid to prostaglandins and is up-regulated in colorectal neoplasms. Evidence …

Epidemiological studies have demonstrated that nonsteroidal anti-inflammatory drugs
(NSAIDs), known to inhibit cyclooxygenase (COX), reduce the risk of colorectal cancer. COX …

Objectives. Cyclooxygenase-1 and 2 (COX-1 and COX-2) play important roles in normal
physiology and are often dysregulated in neoplastic tissues. The present study determines …