The clinical utility of non-steroidal anti-inflammatory drugs (NSAIDs) is limited by their
gastrointestinal and renal toxicities. Indomethacin (an NSAID commonly used in toxicity …

The clinical utility of nonsteroidal anti-inflammatory drugs (NSAIDs) is often limited by the
adverse effects that they produce in the small intestine. Alterations in the composition and …

Zinc may have an antioxidant effect mediated by induction of metallothionein. Based on the
assumption that metallothionein can scavenge oxygen free radicals, we examined whether …

We have demonstrated that Zn supplementation mediated up-regulation of cardiac
metallothionein (MT) as a potent antioxidant prevented the development of diabetic …

Altered zinc homeostasis is one of several metabolic sequelae of inflammation wherein zinc
is redistributed to the liver from endogenous sources such as plasma and sequestered in …

Nonsteroidal anti-inflammatory drugs are used extensively in clinical medicine. In spite of
their therapeutic utility, however, they are known to cause significant gastrointestinal and …

Background: Cadmium is a heavy metal that can cause various injuries in the body,
including nephrotoxicity. L-Arginine is a metal chelator that can prevent oxidative damage …

Effects of metallothionein (MT) on pancreatic endocrine cells of mice, injected with alloxan
and at different zinc status were studied. Mice were given drinking water containing four …

Zinc is an element that under physiological conditions preferentially binds to and is a potent
inducer of metallothionein under physiological conditions. The present study was conducted …

Indomethacin (IndoM) has prominent anti-inflammatory and analgesic-antipyretic properties.
However, high incidence and severity of side-effects on the structure and functions of the …