Cross-talk between adipose tissue and central nervous system (CNS) underlies the
increased risk of obese people to develop brain diseases such as cognitive and mood …

Obesity has various deleterious effects on health largely associated with metabolic
abnormalities including abnormal glucose and lipid homeostasis that are associated with …

Alzheimer's disease is the leading cause of dementia and the most prevalent
neurodegenerative disease. It is an aging-related multi-factorial disorder and growing …

Global levels of obesity are reaching epidemic proportions, leading to a dramatic increase in
incidence of secondary diseases and the significant economic burden associated with their …

Obesity is a pandemic and a serious global health concern. Obesity is a risk factor for
multiple conditions and contributes to multi-morbidities, resulting in increased health costs …

First seen as a fat-storage tissue, the adipose tissue is considered as a critical player in the
endocrine system. Precisely, adipose tissue can produce an array of bioactive factors …

There is accumulating evidence from epidemiological studies that changes in body weight
are associated with Alzheimer's disease (AD) from mid-life obesity increasing the risk of …

Circulating adiponectin (APN) levels decrease with age and obesity. On the other hand, a
reduction in APN levels is associated with neurodegeneration and neuroinflammation. We …

Background and purpose: Life style‐related disorders such as hypertension, diabetes,
dyslipidemia, and obesity are reported to be a great risk of dementia. Adipocytokines …

Level of adiposity is linked to manifest dementia and Alzheimer's disease in epidemiological
studies. Overweight and obesity in mid-and late-life may increase risk for dementia, whereas …