The discovery of the obese gene and the demonstration that its encoded protein leptin can
reverse obesity due to genetic deficiency of the hormone were landmark discoveries in …

Recent advances indicate that a robust physiologic system acts to maintain relative
constancy of weight in mammals. A key component of this system is leptin. Leptin is an …

The discovery of leptin changed the view of adipose tissue from that of a passive vessel that
stores fat to that of a dynamic endocrine organ that actively regulates behaviour and …

A chronic minor imbalance between energy intake and energy expenditure may lead to
obesity. Both lean and obese subjects eventually reach energy balance and their body …

The cloning of the gene responsible for obesity in the ob/ob mouse in 1994 and the resulting
discovery of leptin (1) has spawned a flurry of investigation into the biology of this novel …

▪ Abstract The discovery of the adipose-derived hormone leptin has generated enormous
interest in the interaction between peripheral signals and brain targets involved in the …

Leptin has received considerable attention as a newly recognized metabolic hormone and
for its potential for therapeutic use in the treatment of human obesity. Furthermore, defects in …

Food restriction and weight loss result in reduced plasma leptin, which is associated with a
pleiotropic biologic response. However, because weight loss itself is also associated with …

The identification of the ob gene through positional cloning (1) and the demonstration that its
protein product leptin reverses the obesity–diabetes syndrome in ob/ob mice (2–4) have …

Much attention has focused on the effects of leptin as a central satiety agent. There is now a
significant amount of evidence that leptin is active in the periphery. This review focuses on …