The rostral ventromedial medulla (RVM) projects to the medullary and spinal dorsal horns
and is a major source of descending modulation of nociceptive transmission. Traditionally …

The role of the periaqueductal gray-rostral ventromedial medulla (RVM) system in
descending inhibition of nociception has been studied for over 30 years. The neural basis …

Decades of research have suggested that stimulation of supraspinal structures, such as the
periaqueductal gray (PAG) and rostral ventromedial medulla (RVM), inhibits nocifensive …

Top–down processing pathways modulate neuronal transmission at the level of the spinal
cord dorsal horn and thus govern, in part, the percept of pain. In health, these descending …

A myriad of complex processes marry to drive pain perception in health and chronicity. A
final step in proceedings involves the activation of top-down modulatory pathways that can …

The rostral ventromedial medulla (RVM) forms part of a descending pathway that modulates
nociceptive neurotransmission at the level of the spinal cord dorsal horn. However, the …

The ability to modulate pain perception is as critical to survival as pain itself. The most
known pain modulation pathway is the PAG–RVM (periaqueductal gray–rostral …

Abstract Purpose of Review The goal of the review was to highlight recent advances in our
understanding of descending pain-modulating systems and how these contribute to …

The rostral ventromedial medulla (RVM) exerts bidirectional descending modulation of pain
attributable to the activity of electrophysiologically identified pronociceptive ON and …

In contrast to a classic view that the brain was a passive receiver of the pain message,
Melzack and Wall proposed in 1965 that the brain exerted descending control upon spinal …