Pharmacokinetic and Pharmacodynamic Interactions between Simvastatin and Gardeniae Fructus in Healthy and High-fat High-cholesterol Diet Induced …
Z Li - 2020 - search.proquest.com
Background: Liver injury potentially induced by interactions between simvastatin and
Gardeniae Fructus in patients with symptoms of non-alcoholic steatohepatitis (NASH) was …
Gardeniae Fructus in patients with symptoms of non-alcoholic steatohepatitis (NASH) was …
Intestinal absorption and hepatic elimination of drugs in high‐fat high‐cholesterol diet‐induced non‐alcoholic steatohepatitis rats: exemplified by simvastatin
Z Li, J Zhang, Y Zhang, L Zhou, J Zhao… - British Journal of …, 2021 - Wiley Online Library
Background and Purpose Altered drug pharmacokinetics is a significant concern in non‐
alcoholic steatohepatitis (NASH) patients. Although high‐fat high‐cholesterol (HFHC) diet …
alcoholic steatohepatitis (NASH) patients. Although high‐fat high‐cholesterol (HFHC) diet …
Disease Status–Dependent Drug–Herb Interactions: NASH Lowered the Risk of Hepatotoxicity in Rats Coadministered With Simvastatin and Gardenia jasminoides J …
Concurrent use of simvastatin (SV) and Gardenia jasminoides J. Ellis (GJ) was adopted in
patients with multi-morbidity, such as stroke rehabilitation patients with NASH. Although …
patients with multi-morbidity, such as stroke rehabilitation patients with NASH. Although …
Evodiamine decreased the systemic exposure of pravastatin in non-alcoholic steatohepatitis rats due to the up-regulation of hepatic OATPs
R Liang, W Ge, B Li, W Cui, X Ma, Y Pan… - Pharmaceutical …, 2022 - Taylor & Francis
Context Patients with non-alcoholic steatohepatitis (NASH) may have a simultaneous intake
of pravastatin and evodiamine-containing herbs. Objective The effect of evodiamine on the …
of pravastatin and evodiamine-containing herbs. Objective The effect of evodiamine on the …
The hepatoprotective effect of the combination use of Fructus Schisandrae with statin–A preclinical evaluation
Abstract Ethnopharmacological relevance Fructus Schisandrae is traditionally used as a
liver-toning Chinese herb. Recent studies suggested Fructus Schisandrae could prevent …
liver-toning Chinese herb. Recent studies suggested Fructus Schisandrae could prevent …
Rosuvastatin ameliorates high‐fat and high‐cholesterol diet‐induced nonalcoholic steatohepatitis in rats
Y Okada, K Yamaguchi, T Nakajima… - Liver …, 2013 - Wiley Online Library
Abstract Background/Aims Statins, which are inhibitors of 3‐hydroxy‐3‐methylglutaryl
coenzyme A reductase and inhibit endogenous cholesterol synthesis, possess pleiotropic …
coenzyme A reductase and inhibit endogenous cholesterol synthesis, possess pleiotropic …
Differential Effects of Silymarin on Pitavastatin Disposition in Rodent Models of Simple Fatty Liver versus Nonalcoholic Steatohepatitis: A Natural Product‐Disease …
D Tian, M Gastecki, KD Lynch, T Arman… - The FASEB …, 2019 - Wiley Online Library
Nonalcoholic fatty liver disease (NAFLD) progresses from simple fatty liver (SFL) to
nonalcoholic steatohepatitis (NASH). This progression alters hepatic organic anion …
nonalcoholic steatohepatitis (NASH). This progression alters hepatic organic anion …
[HTML][HTML] Metabolomics profiling to investigate the pharmacologic mechanisms of berberine for the treatment of high-fat diet-induced nonalcoholic steatohepatitis
Objective. Berberine has been used to treat nonalcoholic steatohepatitis (NASH), which has
been addressed in many studies. In this study, we investigated the molecular pharmacology …
been addressed in many studies. In this study, we investigated the molecular pharmacology …
CGplus, a standardized herbal composition ameliorates non-alcoholic steatohepatitis in a tunicamycin-induced mouse model
ABSTRACT Background The prevalence of Non-alcoholic fatty liver disease (NAFLD)
including non-alcoholic steatohepatitis (NASH) has increased by 15–39% worldwide, but no …
including non-alcoholic steatohepatitis (NASH) has increased by 15–39% worldwide, but no …
Nutritional status affects fluvastatin-induced hepatotoxicity and myopathy in rats
J Sugatani, S Sadamitsu, M Kurosawa, S Ikushiro… - Drug metabolism and …, 2010 - ASPET
Rats that consumed a high-fat and high-sucrose diet (HF diet) developed hepatic steatosis.
Treatment of HF diet-fed rats with fluvastatin (8 mg/kg) was lethal, followed by an elevation in …
Treatment of HF diet-fed rats with fluvastatin (8 mg/kg) was lethal, followed by an elevation in …
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