Malaria imposes a horrific public health burden–hundreds of millions of infections and
millions of deaths–on large parts of the world. While this unacceptable health burden and its …

Malaria, a disease caused by the protozoan parasite Plasmodium, remains a serious
healthcare problem in developing countries worldwide. While the host–parasite relationship …

Mouse models have demonstrated utility in delineating the mechanisms underlying many
aspects of malaria immunology and physiology. The most common mouse models of …

Malaria comprises a spectrum of disease syndromes and the immune system is a major
participant in malarial disease. This is particularly true in relation to the immune responses …

Malaria kills close to a million people every year, mostly children under the age of five. In the
drive towards the development of an effective vaccine and new chemotherapeutic targets for …

Malaria parasite infection continues to inflict extensive morbidity and mortality in resource-
poor countries. The insufficiently understood parasite biology, continuously evolving drug …

Malaria remains a deadly parasitic disease caused by Plasmodium, claiming almost half a
million lives every year. While parasite genetics and biology are often the major targets in …

Infection by malaria parasites (Plasmodium spp.) remains one of the leading causes of
morbidity and mortality, especially in tropical regions of the world. Despite the availability of …

Highlights•Plasmepsin IX and X are essential for parasite egress and invasion in rodent and
human malaria throughout the Plasmodium life cycle.•Efficient genetic manipulation of …

Accumulating evidence provides strong support for the importance of innate immunity in
shaping the subsequent adaptive immune response to blood-stage Plasmodium parasites …